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20 Phase I Selections from the 99.1 Solicitation

(In Topic Number Order)
CREARE, INC.
P.O. Box 71
Hanover, NH 03755
Phone:
PI:
Topic#:
(603) 643-3800
James J. Barry
CBD 99-101
Title:Predicting Performance of Protective Clothing Systems
Abstract:Modern protective clothing provides effective protection from chemical agents in most situations but can impose significant thermal stress on the wearer under some battlefield conditions. Currently, design of protective garments relies on slow and costly trial-and- error laboratory testing to assess performance. The proposed project will develop advanced computational models for a clothed human that will enable the military to develop new and improved protective clothing more rapidly and less expensively. The models utilize state- of-the-art computational fluid dynamics (CFD) software to model the transport and sorption of chemical agents and the heat transfer due to convective, diffusive, and phase change through the clothing layers. In Phase I, proof-of-principle models of a static clothed human will be developed and demonstrated During Phase II, complete moving grid models for a clothed soldier will be developed. BENEFITS: The proposed models will reduce the cost and time required to develop new protective garments while helping to improve their performance. These models will have direct and immediate application in development of improved garments for protection from chemical threats and can be used in modeling other military clothing. Commercially, the models have application in the design of industrial garments and advanced outdoor clothing.

INSTITUTE FOR LASER TECHNOLOGY (ILT)
P.O. Box 2070
Rolling Hills, CA 90274
Phone:
PI:
Topic#:
(310) 377-7092
Milton Birnbaum
CBD 99-102
Title:Opo Wavelength Tuner
Abstract:The Institute for Laser Technology (ILT), as the prime contractor, the University of Southern California Center for Laser Studies (USC-CLS) and Raytheon Systems Company, as subcontractors, propose to develop a compact, robust, OPO tuner for solid state lasers that can be integrated with fieldable sensors for the detectionof chemical and biological agents. Initial application to manportable sensors is envisioned with straightforward extension to other platforms such as unmanned aerial vehicles where size and weight are critical design factors. The tuner will utilize simple opto-mechanical assemblies and control electronics and it will be applicable to wavelength shifting in the 3-5 and 8-12 micron bands at a shift rate of at least 50 Hz. The main objective of the Phase I effort is to demonstrate wavelength shifting accuracy and repeatibility as a basis for the Phase IT effort under which a prototype unit will be developed and delivered. BENEEFITS: The proposed tuner is a critical component of chemical and biological agent standoff sensors that would provide the military with a much needed capability. The technology is directly applicable to the important civilian application of pollution monitoring.

Q-PEAK, INC.
135 South Road
Bedford, MA 01730
Phone:
PI:
Topic#:
(781) 275-9535
Dr. Yelena Isyanova
CBD 99-102
Title:Broadly Tunable, High Repetition Rate, 10-W Average Power IR Laser Source
Abstract:Q-Peak, Inc. proposes to develop a broadly tunable, l0-W-average-power IR source suitable for use as a DIAL system transmitter and based on the combination of a Nd-doped pulsed pump laser and optical parametric oscillators (OPO) The laser source, a compact, diode-pumped, 5-10 kHz pulse-repetition-rate, Q-switched Nd:YLF laser, will pump a tandem OPO system consisting of an angle-tuned, 3-5 um KTA OPO, and a pump-tuned, 8-12 um CdSe QPO pumped by the KTA OPO idler. Diode-pumping and nonlinear conversion will substantially increase the efficiency of the proposed source whereas high pulse rates and fast wavelength switching will allow the possibility of reducing the data acquisition time. The Phase I effort will demonstrate a laboratory breadboard 2.5-5 W JR transmitter and develop a design for a higher-efficiency l0-W, 3-12 um tuning range IR-source. BENEFITS: Laser Source will enhance selectivity and sensitivity of chemical and biological agent identification in a low cost standoff detector. In the commercial sector the applications include wide-area pollution monitoring, process control and general scientific investigations.

JCP TECHNOLOGIES, INC.
UW/WTC 135 Fluke Hall, Box 352140
Seattle, WA 98195
Phone:
PI:
Topic#:
(206) 616-2475
Eva Aw
CBD 99-103
Title:Modular Microfluidic Interconnections
Abstract:Microfluidic technology makes available a miniaturized means by which chemical reactants can be brought together on the microscale, fluidic sampling and dispensing can be automated, and the unique properties of low Reynolds number flow can be used to achieve new methods for fluid and sample separation, mixing, and analysis. Much progress has been made in technologies requiring the use of microfluidics, but a fundamental problem that still remains is the interface by which microfluidic systems are connected to the larger, macroscopic world. Thus far, most laboratory prototype systems have relied upon bulky, expensive, and fragile small-bore tubing and connectors for interconnections. HPLC fittings and tubing are very popular for this purpose. Even while the microfluidic system can in some cases be inexpensively produced by batch fabrication methods, the introduction of small-bore tubing and connectors increases the cost of such a system drastically. JCP Technologies proposes to develop a new strategy for modular microfluidic interconnections based upon a novel means for microfabrication called soft lithography. This strategy will emphasize modularity, low cost of manufacture, adaptability to the existing methods of fluidic interconnects, low dead volumes, and the ability to be disassembled and reassembled with precision, positive fastening mechanisms. BENEFITS: The proposed work will provide for the microfluidics markets what printed circuit boards have allowed in the electronics industry-the integration of multiple micro devices and macrosystems. By this means, the advantages of microfluidic systems can be employed to address macro-world problems. This technology will make microfluidics practical and allow their significant medical, environment, and industrial markets to be realized.

MESOSYSTEMS TECHNOLOGY, INC.
3200 George Washington Way
Richland, WA 99352
Phone:
PI:
Topic#:
(509) 375-1111
Donald J. Hammerstrom, Ph
CBD 99-103
Title:Portable Intergrated Collector & Detector System Interfaced for Use With a Variety of Emerging Biological Warfare Agent Detectors
Abstract:We propose to design and build a generic aerosol collector and detector interface that will incorporate a MesoSystems aerosol collector, fluidic delivery system, lysis stage, electronic control system, and the Utah State University whole cell detector, which serves as an example of the types of BW detectors now emerging for military use. The resulting prototype portable detector will be functional at the conclusion of Phase I, but additional work on the plasma lysis section and polymerase chain reaction (PCR) interconnection will not be completed until the Phase I option and Phase II awards are granted Special design effort will be spent on making a flexible, disposable reagent cartridge that solves many of the fluidic interconnection problems and biological warfare (BW) instrument contamination concerns. BENEFITS: MesoSystems will drive the standardization of the interfaces because of: Micromachining experience Collector miniaturization Microfluidic work Familiarly with detectors.

COMBIMATRIX CORP.
887 Mitten Road, Suite 200
Burlingame, CA 94010
Phone:
PI:
Topic#:
(650) 697-5115
Dr. Kilian Dill
CBD 99-104
Title:Nanode Array Sensor Microchips
Abstract:CombiMatrix employs CMOS integrated circuitry to produce analog VLSI arrays of individually addressable electrodes. Existing electrode array chips will be modified to make arrays of nanometer-scale ultramicro electrodes. These chips will be used to develop assays for chemical and biological warfare agents. Assays will use highly selective immunochemical methods. The advantageous electrochemical properties of nanodes will be exploited to improve the limits of detection and speed of these biochip sensor devices. Further, CombiMatrix hardware and manufacturing methods allow for multiplexing numerous assays onto a single biochip. Multiplexed assays will be demonstrated. BENEFITS: This proposal will have direct application to development of portable environmental sensor devices, as well as biochip applications such as genomics, proteomics, and drug discovery.

MATERIALS & ELECTROCHEMICAL RESEARCH CO.
7960 S. Kolb Road
Tuscon, AZ 85706
Phone:
PI:
Topic#:
(520) 574-1983
Dr. R. O. Loutfy
CBD 99-104
Title:Carbon Nanofiber Electrode Arrays for the Integration Into On-Chip Electrochemical Biosensor Systems
Abstract:Electrochemical systems are among the most promising candidates for the miniaturization of chemical and biological sensors due to their close association with today's advanced semiconductor technology. Further miniaturization of the electrochemical part is expected to enable on-chip integration of the sensors. The result will be a highly portable microanalytical sensor system with fast response time and high selectivity. It is proposed to use arrays of carbon nanofibers as ultimate nanosize electrodes. The fibers can be produced well aligned and with good mechanical strength on a variety of substrates. MER's experience in the fabrication and tailoring of carbon nanofibers will be utilized to produce nanofiber structures, which meet the requirements for nanoelectrode arrays. Existing electronic designs will be used to interface the microelectrode arrays and to obtain electrochemical data. Redox modifying compounds will be immobilized on the electrode surface to improve selectivity and sensitivity of the electrode arrays towards biological agents. BENEFITS: Besides an improvement of the safety of battlefield personnel, handheld biosensors with fast response time and good selectivity could be used in clinical health care applications, pharmaceutical production and in agricultural applications. These devices could also be used for the detection of chemical agents.

HAWAII BIOTECHNOLOGY GROUP, INC.
99-193 Aiea Heights Drive, Suite 236
Aiea, HI 96701
Phone:
PI:
Topic#:
(808) 486-5333
Xianglong Zou, Ph.D.
CBD 99-105
Title:Synthesis of Dimercapturic Acid-Protein Conjugates For Production of Immunological Regants
Abstract:Chemical weapons are highly lethal, inexpensive weapons of mass destruction. Present methods for detection of exposure to sulfur mustard are expensive and time-consuming. Accordingly, there is an urgent need for the development of rapid, simple, and reliable detection methods capable of monitoring of toxic compounds for clinical treatment and diagnosis after exposure to sulfur mustard. In phase I, we propose the syntheses of four analogs of bis ((2-acetylamino-2-carboxyethylthio) ethyl) sulfone and their conjugates with two carrier proteins (KLH and BSA) for production of antibodies and immunoassay development. Haptens will be coupled with carrier proteins through either the central sulfur atom or terminal amino group via a linker. BENEFITS: An immunoassay for rapid determination of exposure to sulfur mustard would contribute to improved diagnosis and treatment of individuals during military or terroristic acts.

SYNQUEST, INC.
2225 W. Harrison Street
Chicago, IL 60612
Phone:
PI:
Topic#:
(312) 421-1819
Sudersan Tuladhar
CBD 99-105
Title:Synthesis of HD-Related Hapten - Protein Conjugates
Abstract:A hapten based upon the molecular structure of a metabolite of sulfur mustard (HD), namley bis(2-acetylamino-2-carboxyethylthio)ethyl) sulfoximine, (dimercapturate)2S(O)Nhwill be synthesized. This will be conjugated with proteins to yield the antigenic haptens (dimercapturate)2S(O)N-HSA,BSA and-PTG. Preliminary studies will be carried out using the know (CH3)2S(O)NH. A phosphorus atom marker unit will be covalently attached to each hapten protein conjugate and the hapten: protein ratio will be determined by 31p NMR. A hapten will be synthesized using the terminal carboxyl group of the same metabolic substrate as the site for conjugation to BSA. The antigenic haptens will be used for the production of monoclonal antibodies, which in tLLm will be applied to the development of a noninvasive immunodiagnostic test for exposure to sulfur mustard. Such a test device would be use fill for the detection of sulfur mustards used in chemical warfare agents in combat or by terrorists. Commercial applications would result from use of the detection device forensically by local, state and federal agencies. BENEFITS: Device for sulfur mustard(HD) fits a need for early detection of this chemical agent in the battlefield as well as in terrorist activities. This device would be acquired by local, state, and other government agencies. Foreign governments involved in combatting terrorism would be candidates for this method.

NANODELIVERY, INC.
5123 Virginia Way, Suite C-21
Nashville, TN 37027
Phone:
PI:
Topic#:
(615) 221-9022
Ales Prokop
CBD 99-106
Title:Development of Naked DNA Vaccine: Brucella
Abstract:This Phase I Proposal aims to maximize gene transfer by means of polymeric-based micellar and nanoparticulate delivery vehicles in order to elicit protective immunity against Brucella. In-vitro cell mediated cytotoxicity and in-vivo pathogen protection in a challenge test will be demonstrated. For Phase I Option we will further characterize the protective immunity by means of cellular and humoral responses and analyze the protective effect over an extended period of time. BENEFITS: Development of protective (and therapeutic) vaccine against Brucella as a commercial product

RESEARCH INTERNATIONAL, L.P.
18706 142nd Ave. N.E.
Woodinville Stat, WA 98072
Phone:
PI:
Topic#:
(425) 486-7831
Elric W. Saaski
CBD 99-201
Title:A Hand-Held Evanescent Wave Multi-Analyte Biosensor With Fully Disposable Assay Components
Abstract:The development of equipment that requires extensive fluid manipulation, such as analytical diagnostic tools, has generally lagged behind those of a purely electromechanical nature, even though obvious demand exists in areas as diverse as medicine, environmental monitoring, food safety, and counter-terrorism. We propose a self-contained, miniaturized bioassay system that is capable of simultaneously detecting and quantifying the presence of 6 to 10 analytes in a single sample of less than 500 microliters volume. Such a diagnostic device has clear applicability to many industrial, medical and military sectors. This handheld, multi-analyte, wet-chemistry diagnostic system will measure diverse water-borne analytes at concentrations ranging to below one part per billion. The system will be constructed by the integration of state-of-the-art digital and analog circuitry with novel miniaturized fluid handling technologies, optics, and highly specific antibody-based assay techniques. All analyte-specific assay components will be incorporated in a disposable molded plastic coupon, allowing the system to detect and quantify a wide range of chemicals, proteins, viruses, bacteria and biological fragments by simply changing coupons. The proposed system allows coupon re-use until a strong positive showing occurs, greatly reducing costs in applications such as counter-terrorism where most measurements will produce negative responses. BENEFITS: Environmental, medical and public safety monitoring applications currently exist and await functional, affordable instrumentation.

PHYSICAL OPTICS CORP.
Engineering & Products Div., 20600 Gramercy, #100
Torrance, CA 90501
Phone:
PI:
Topic#:
(310) 320-3088

CBD 99-202
Title:High Surface Area Film Filter
Abstract:Physical Optics Corporation proposes to develop a high surface area flm filter (HiSAFF) for high efficiency particulate air(HEPA) filtration. Current HEPA filters, while effective, are limited in their performance by significant pressure drop, inability to be effectively and easily cleaned, insufficient particle loading capacity, and excessive cost of manufacture. The proposed HiSAFF media is based on readily available, inexpensive holographic diffuser material. The compact, nonfibrous HiSAFF filter, which has a predictable architecture, high bipolar charge density, and low air resistance, is superior because it is highly efficient produces low pressure drop, can be easily cleaned and reused, and can be produced at low cost using mature fabrication techniques and commercial materials. In Phase I, design and performance testing of the HiSAFF will be completed; the filter will be evaluated for probability of success and Joint Service use. Successful completion of Phase I will lead to further development and optimization for filtering particulates 0.3 micron or smaller, to be completed in Phase II.BENEFITS: This project will lead to low-cost, high performance, reusable HEPA/ULPA filter technology that can be used in a wide range of biomedical and industrial facilities including hospitals, clinical and research labs, clean rooms, and nuclear plants. List a maximum of 8 Key Words that describe the Project.

FEDERAL FABRICS-FIBERS
21 Marie Drive
Andover, MA 01810
Phone:
PI:
Topic#:
(978) 470-1859
Fred Geurts
CBD 99-203
Title:Extrusion Cast Cost Effective Chemical Protective
Abstract:With the increase threat of chemical and biological warfare (CBW), each and every shelter should have all the features to protect the troops from CBW. The one and only reason that the troops are not protected from CBW unconditionally as a doctrine, is cost. The high cost resulting from difficult fabrication, low durability, and inadequate fire resistance, weight and bulk problems defined in the solicitation. To provide adequate protect against chemical warfare agents (CWA) requires a chemically inert and impermeable film. The barrier film must be inert to withstand absorption of and degradation by the chemical threat. Inertness of the barrier it is also necessary to allow simple decontamination procedures. Many low cost films are both flammable and difficult to decontaminate. While many film materials are impermeable, only a few fluorinated films will provide all the properties required. Most fluorinated resins suitable for film fabrication are not tough enough for the application, mainly due to their high elastic modulus, which makes those films overly stiff with low elongation, this property tends to reduce their resistance to mechanical punishment. Designing a CBW protective fabric that will result in low life cycle cost shelter will increase the likelihood of such a fabric to be incorporated into each and every military shelter, thus bringing about the economy of scale required to reduce the cost even further. A generic solution for applying an CB impermeable resin to FR fabric would potentially address both the disposable and the decontamination requirements. BENEFIITS: Cost effective chemical barrier materials with low permeation properties can be used throughout industry as a means of reducing VOC's emissions.

TRITON SYSTEMS, INC.
200 Turnpike Road
Chelmsford, MA 01824
Phone:
PI:
Topic#:
(978) 250-4200
Bryan Koene, Ph.D.
CBD 99-203
Title:Enhanced Technology for Chemical and Biological (CB) Agent Resistant Flexible Companies
Abstract:Triton Systems proposes to combine its innovative polymer-clay nanotechnology with chemically resistant polymers to develop revolutionary flexible nanocomposite materials that will provide significant performance improvements and also reduce the cost of chemical and biological (CB) protected tentage. Our innovative approach will produce tentage materials that (i) have superior chemical, biological, flame, UV, and abrasion resistance (ii) and will yield a substantially reduced cost to allow increased availability of these materials across the battlefield. This proven nanotechnology has already shown increased chemical, flame, and abrasion resistance in various polymer matrices. BENEFIITS: This successful phase I will develop an enabling technology that will benefit many areas where chemical agent resistance and/or flammability are required. These include fabrics in protective clothing for chemical manufacturer workers and for toxic cleanup Suits.

SIMULATION TECHNOLOGIES, INC.
111 West First Street, Suite 748
Dayton, OH 45402
Phone:
PI:
Topic#:
(410) 638-0898
Dennis F. Metz
CBD 99-204
Title:3D Chem/Bio Response Trainer
Abstract:A terrorist incident involving chemical/biological (CB) weapons may occur as a local event with potentially profound national implications Such an incident may occur at a US military base, a US federal, state or local agency or a civilian entity. Regardless of where the incident has occurred, first responders must be able to provide critical resources within minutes to mitigate the effects of the incident. First responders may be civilian or military personnel. First responders need awareness training specific to CB hazards so that they can quickly recognize victim symptoms and other characteristics of such an incident which may distinguish them from other hazardous material incidents. In addition, first responders also need training on routes of exposure, means of protection, health effects, treatment and monitoring, decontamination methods, handling of mass casualties and triage. Saving lives Immediately after a CB incident requires quick and accurate action. Three dimensional (3D) virtual world technology can be used to train medical and support personnel in the set-up of the different CB response stations and areas (e.g., triage, decontamination and stabilization). Details of the Hot Zone, Warm Zone and Cold Zone could be shown in the safety of a 3D virtual world. Development and utilization of this type of system could be programmed with specific tests to ensure the user learns the key points. BENEFITS: Creation of a prototype CB incident response trainer simulation will I provide the framework and underlying concept upon which a more comprehensive and robust virtual reality simulation can be developed. The simulation has commercial usage by emergency incident response departments in major urban centers, at major trauma centers and in medical schools.

MESOSYSTEMS TECHNOLOGY, INC.
3200 George Washington Way
Richland, WA 99352
Phone:
PI:
Topic#:
(509) 375-1111
Donald J. Hammerstrom, Ph
CBD 99-205
Title:Unattended Sensors in a Sonobuoy for Chemical and Biological Defense
Abstract:A sonobuoy is a remote, floating reconnaissance sensor that can be launched far from the site of interest and can report back information to remote observers on land or on vessels. MesoSystems Technology, Inc. proposes to collaborate with Johns Hopkins University-Applied Physics Laboratory (JHU_APL) to produce an unattended chemical and biological sensor based on mass spectrometry in a sonobuoy. The chemical sensor approach builds on the significant amount of research performed there to date on the identification of vapor species by ion-mobility mass spectrometry. The biological sensor approach is based on recent developments by JHU-APL concerning matrix-assisted laser desorption ionization (MALDI) mass spectrometry. While the chemical sensor approach has a long history, MALDI has only recently been applied to the rapid screening of bio-pathogens. The integration of aerosol collectors, MALDI detection, and the somobuoy platform is of interest because it would have 7 Low sample volume requirements (less than I microliter of fluid) ? Rapid analysis time (< 1 minute per sample) ? Fingerprint identification of bacteria and spores has been made by the comparison of pure cultures and simple microbial mixtures against a library of known MALDI spectra. BENEFITS: The chemical and biological warfare detection sonobuoy platform will prove to be a useful and life-saving defense technology by keeping armed forces far from sites where chemical and biological agents are suspected.

NAVMAR APPLIED SCIENCES CORP.
65 West Street Road, Suite B-104
Warminster, PA 18974
Phone:
PI:
Topic#:
(215) 675-4900
Carl Calianno
CBD 99-205
Title:Air Deployed Chemical and Biologic Sensor
Abstract:This SBIR proposes the development of an expendable sonobuoy-like "system" for forward placement/standoff detection of CheniicaL/Biological(CB)agents. Variants of the system may provide affordable monitors for commercial CB detection applications. The technical objective is to formulate a design concept and demonstrate the feasibility of deploying and housing new or advanced CB sensors in an air-deployed expendable CB sensor system. The program goal is to develop a system to obtain real time, CB data in forward areas such as amphibious landings, battlefield positions, or vacated/dewstroyed enemy positions and telemeter the information via novel monitioring techniques to the on-scene aircraft or satellites for integration into a Network Centric Command, Control, Computers, Communications and Intelligence (C4I) architecture. The latest command and control processes and mechanism for rapid automated battle space awareness will be implemented. A system design concept providing flexibility through modular packaging, method of deployment and implantment, autonomous operation, data storage, processing and monitoring is proposed. Novel system techniques will include deployment and implanting, sensor layout and packing, sensor configuration and chamber orientation, tactical employment (number of sensors required for each area search), wind velocity and direction sensor, dual telemetry and antenna plus growth potential for seismic and acoustic detection sensors. BENEFITS: Successful development of an affordable sonobuoy-type expendable CB sensor will dramatically increase the warfighters survivability and early warning in a potential CB environment. Commercial market potential covers all CB aspects of civil defense, domestic and foreign terrorists. Units could he made available for schools, subways, airports and other commercially visited sites by the U.S. population.

DCS CORP.
1330 Braddock Place
Alexandria, VA 22314
Phone:
PI:
Topic#:
(703) 683-8430
Edwin Gaynor
CBD 99-301
Title:Chemical and Biological Mask Optical Model for Mask Design Aid
Abstract:In the proposed program, we will create a Mask Optical Model algorithm set and a Design Aid interface that will predict the effect of varying mask parameters on the effectiveness of external optical weapons sighting systems. The design aid will be used by designers of chemical and biological protective masks. It will eventually interface with other developing design aids that parametrically model the facemask interface stresses and performance effects. Focus in Phase I will be on the optical system comprising the AN/PvS-7 night vision device, the Army M-40 mask and the eyes of the wearer. The results of initial tests will be used to quantify the metrics of the system. We will then develop algorithms that relate mask design metrics to optical system metrics. The algorithms will be demonstrated using a metric database and graphics. In Phase II, we will fully develop the design aid for use by a designer. We will insert into the database optical parameters of current and future night sights, night vision goggles, binoculars, rifle sights; for instance the Air Force NOVA-8 60-degree FOV goggles and AN/AVS-9 night vision system. The system will accept design parameters for current M40/ M42 mask and future Joint Service masks. BENEFITS: The Mask Optical Model algorithm and Design Aid interface will improve the quality and production rate of chemical/biological protective facemasks, and so will result in significant time and cost savings in the design and reduction of the chem/bio risk to soldiers in the field.

PRECISION RESEARCH, INC.
1010 35th Street
Kenosha, WI 53140
Phone:
PI:
Topic#:
(414) 658-4550
Neal Sleszynski
CBD 99-302
Title:Detection of Biological Agents and Pathogens in Water
Abstract:This Small Business Innovation Research Phase I will develop a method and portable instrument design for the separation and analysis of bacteria in water samples. One application is for a field deployable instrument to screen for biological warfare agents. Automation and rapid analysis times are required for this application. One problem with conventional biological assay techniques is the delay in being able to identify the infectious agent. Another issue is the isolation of the infectious species. The identification of antibodies to various bacteria is allowing an advance in immunoassay technology. Many new test kits are emerging for testing in clinical and food applications. Another emerging technique for biological analysis is capillary electrophoresis. This analytical tool has been used to separate and identify proteins, drugs, viruses, nucleotides, and other biochemical species. By combining the advantages of immunoassays and capillary electrophoresis, new analytical techniques can be developed with synergistic capabilities for the rapid separation, isolation, and analysis of bacteria. Once the technique is optimized, small portable instruments will be designed for field-deployable applications. BENEFITS: This Research will provide a new analytical methodology to develop a portable diagnostic instrument that will aid in the separation, isolation, and identification of bacteria in water samples. Faster and improved analysis methods of bacteria will aid in treatment and protection of the military and civilian populations.

PHYSICAL SCIENCES, INC.
20 New England Business Center
Andover, MA 01810
Phone:
PI:
Topic#:
(978) 689-0003
William J. Marinelli
CBD 99-303
Title:Infrared Standoff Bio-Agent Discrimination
Abstract:Physical Sciences Inc. (PSI), along with its development partner ITT Systems and Sciences Inc. (ITT) , proposes to develop an innovative compact and high power infrared LIDAR system for the standoff detection and discrimination of biological aerosols at ranges approaching 10 km. Our approach anticipates the use of the signal (~l.55 um) and idler (~3.45 pm) wavelengths from a solid state optical parametric oscillator (OPO) transmitter to provide a ratio of returns which is unique to biological aerosols and clearly differentiable from normal aerosol backgrounds, thereby performing the discrimination task. This approach may be extended through the use of wavelength tuning in the signal channel to detect the chemical signature of growth media which are co-distributed in the agent containing aerosol. The key innovation in the development of the LIDAR is in the configuration of the OPO cavity, which resonates on the idler and only extracts the signal on the last pass through the cavity. Consequently, the output of the device tends to follow the beam quality of the pump device -providing low divergence with good beam profile which enhances conversion efficiency. The effort also addresses key uncertainties in the magnitudes of aerosol backscatter coefficients which are key to bio-agent discrimination. BENEFITS: The anticipated result of a combined Phase I and Phase II effort is the development and delivery of a novel OPO-based LIDAR capable of discriminating bio-aerosols from natural atmospheric aerosols and interferents at ranges up to 10 km. Commercialization of the proposed technology will include: the productization of compact OPO technology for sales in to the scientific and remote sensing community, and direct sales of OPO-based LIDARs to the US government and allied countries for support of their existing efforts to achieve readily deployable standoff biological agent detection capability.