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26 Phase I Selections from the 00.1 Solicitation

(In Topic Number Order)
MESOSYSTEMS TECHNOLOGY, INC.
3200 George Washington Way
Richland, WA 99352
Phone:
PI:
Topic#:
(509) 375-1111
Yin-Fong Su
CBD 00-101
Title:Miniaturized Sample Preparation Module
Abstract:MesoSystems Technology, Inc. (MesoSystems) proposes to design and build an integrated mesofluidic-based biosensor system to sample and detect pathogens from air and soil. The air sampling pathogen detection system will incorporate a MesoSystems miniature rotating arm aerosol collector that concentrates bio-aerosols into water. The resulting fluid samples, containing the collected bio-aerosols, are sent to a combined pathogen bead concentrator and lysis device. The fluid is minimized by passing the sample through an acoustic concentrator, and conveyed to the polymerase chain reaction (PCR) thermal cycler. After DNA amplification, the labeled sample fluoresces and the intensity is correlated with concentration. This miniaturized bio-detector approach serves as an example of the types of biological warfare (BW) detectors now emerging for military use. We propose a compact, lightweight, BW detector system with fluidic interconnections at a scale somewhat larger than microfluidic. Benefits include a product that is rugged for use in battlefield conditions and that is simple to use by soldiers under duress for BW detection.

Q PEAK, INC.
135 South Road
Bedford, MA 01730
Phone:
PI:
Topic#:
(781) 275-9535
Yelena Isyanova
CBD 00-102
Title:High-Pulse-Rate IR Source for Improved DIAL Sensitivity
Abstract:Q-Peak, Inc. proposes to develop a broadly tunable, 10-W-average-power IR source suitable for use as a DIAL system transmitter and based on the combination of a Nd-doped pulsed pump laser and optical parametric oscillators (OPO). The laser source, a compact, diode-pumped, 1-2-kHz pulse-repetition-rate, Q-switched Nd:YLF laser, will pump a tandem OPO system consisting of an angle-tuned, 3-5 micron KTA OPO, and a pump-tuned, 8-12 micron CdSe OPO pumped by the KTA OPO idler. Diode-pumping and nonlinear conversion will substantially increase the efficiency of the proposed source whereas high pulse rates and fast wavelength switching will allow the possibility of reducing the data acquisition time. The Phase I effort will demonstrate a laboratory breadboard 2.5-5 W IR transmitter and develop a design for a higher-efficiency 10-W, 3-12 micron tuning range IR-source. The proposed IR Laser Source will enhance sensitivity of standoff chemical and biological detection by utilizing a high repetition rate laser source that will allow for the possibility of reducing the data acquisition time. In the commercial sector the applications include wide-area pollution monitoring, process control and general scientific investigations.

SCIENCE & TECHNOLOGY CORP.
10 Basil Sawyer Drive
Hampton, VA 23666
Phone:
PI:
Topic#:
(757) 766-5822
George M. Wood
CBD 00-102
Title:Improved Sensitivity for LIDAR BasedChemical and Biological Standoff Detection
Abstract:The objective of this proposal is to quantitatively enhance the sensitivity of Carbon Dioxide lasers used in the standoff detection of Chemical and Biological agents. This improvement will derive primarily from the development and implementation of algorithms to enhance the real time detection of weak signals using a combination of noise removal, deconvolution, and correlation methods. Additionally, an ambient temperature catalyst developed specifically for stabilizing laser power, enabeling increased operational pulse rates, and extending laser lifetime will be incorporated into the TEA LIDAR Lasers to further improve signal detection capability. The sucessful completion of this research will significantly enhance the ability to detect trace quantities of specified species in real time without major modification to the basic LIDAR technology.It is anticipated that the primary users will be DoD, other Government Agencies such as EPA and FEMA, and local law enforcement, and environmental monitoring departments.STC will, nevertheless, develop the algorithms and catalyst recycling systems in a manner that will effect efficient application to existing and to newly developed systems.

QUANTUM MAGNETICS, INC.
7740 Kenamar Ct.
San Diego, CA 92121
Phone:
PI:
Topic#:
(858) 566-9200
Hector Robert
CBD 00-103
Title:Detection of BW Agents using Quadrupole Resonance Technology
Abstract:Biological warfare agents are a serious and growing threat facing many nations. Because of the ever-present possibility for the use of these agents against civilians, a need exists to detect the contraband and identify such agents. Quantum Magnetics is proposing a new technology to detect contraband of biological warfare (BW) agents concealed in baggage, cargoes, and packages. The proposed detection and identification system is based on Quadrupole Resonance (QR) technology recently developed for detection of explosives, narcotics, and landmines. The state-of-the-art QR sensors allow for quick detection of explosives with short scanning time, high probability of detection, and low probability of false alarms. The objective in Phase I of this project is to evaluate the feasibility to detect small quantities of BW agents using QR sensors. Laboratory tests will be carried out to characterize the signatures of BW simulants, and we will predict the performance of large volume scanners. If Phase I is successful, in the Phase I Option period we will design a prototype of a QR detection system for detection of bacterial spores concealed in baggage or packages. In Phase II we will build the system to demonstrate detection of threat quantities of bacterial spores. The development of BW screening system based on QR technology will provide a reliable and low-cost protection against BW agents. Detection of contraband of BW agents will enhance significantly the defense against this threat. QR-based baggage scanners are easy to operate, require minimum operator training, and provide security in manner that is non-intrusive and safe. Detection of BW agents by QR can be integrated with explosive detection scanners to provide a more complete and powerful protection system.

EIC LABORATORIES, INC.
111 Downey Street
Norwood, MA 02062
Phone:
PI:
Topic#:
(781) 769-9450
Kevin M. Spencer
CBD 00-105
Title:An Advanced SERS Water Monitor for Chemical and Biological Analytes
Abstract:The Joint Service Agent Water Monitor (JSAWM) has several very challenging operational requirements for detecting and monitoring chemical and biological warfare (CBW) contaminants in military water supplies. Surface Enhanced Raman Spectroscopy (SERS) can provide highly specific spectroscopic "fingerprints" of molecules adsorbed onto certain roughened metal surfaces. Recent results at EIC and elsewhere indicate that SERS can be used for ppb level down to single molecule detection, that it can be used to identify chemicals in complex mixtures, and that it can also be used to detect and differentiate bacteria. The overall goal of this program is to develop portable SERS modules that take advantage of these capabilities, leading to a truly universal JSAWM instrument. Phase I will seek to determine the analytical figures of merit of SERS, comparing several types of SERS substrates with respect to detection of characteristic chemical and biological agent analogs in water. A Phase I goal is to demonstrate the required detection limits of at least two CBW analytes. The military has a requirement for >20,000 JSAWM installations. Even larger markets exist for on-line and batch-type government, municipal and industrial water pollution control systems.

TRITON SYSTEMS, INC.
200 TURNPIKE ROAD
Chelmsford, MA 01824
Phone:
PI:
Topic#:
(978) 250-4200
Erik Handy
CBD 00-105
Title:Hand-Held RCC Chemical Agent Water Monitor
Abstract:Triton Systems, Inc. proposes a novel sensor system for rapid detection of water-borne nerve, blister, and blood-poisoning chemical warfare agents (CWA's). Central to Triton's innovation is a "reactive chemical-cascade" (RCC) detection process, whereby single CWA molecules elicit multiple responses from an array of unique polymeric sensing elements. The RCC process allows us to approach detection of CWA's present at parts-per-trillion (ppt) levels. The Triton sensor is portable, inherently safe, and unlike many conventional sensors, utilizes only inexpensive, low-voltage, non-radioactive components. As such, this technology module is readily-integrated into larger, more comprehensive environmental monitoring units. On Phase I, Triton will fabricate sensing elements to demonstrate aqueous CWA simulant/derivative detection at low levels. On the Phase I Option, the RCC sensor device architecture will be optimized to approach detection in the ppt range. On Phase II, Triton will integrate the optimized sensor array with pattern-recognition software and readout hardware in a developmental prototype, which would be packaged and made field-ready in a Phase III commercialization effort. There is a large commercial market for water-based sensors that afford real-time detection of CWA's. Triton's "chemical cascade" sensor has dual use in both demilitarization/ CWA treaty verification and municipal/commercial water supply quality assurance applications. The proposed technology also lends itself well to liquid-phase detection of non-warfare-related chemicals, as in on-line monitoring of industrial chemical reactions and processing. On-line monitoring with the Triton sensor is more cost- and time-effective than post-processing analysis. The Triton sensor technology can be further extended to the implantable medical device market for in vivo chemical monitoring at low concentrations.

MESOSYSTEMS TECHNOLOGY, INC.
3200 George Washington Way
Richland, WA 99352
Phone:
PI:
Topic#:
(509) 375-1111
Yin-Fong Su
CBD 00-106
Title:Development of a Miniaturized Biological Detector
Abstract:The proposed approach is to miniaturize a biological detector by: Capturing aerosols using a micromachined virtual impactor collector or MesoVICTM to deposit them on a tape surface for subsequent analysis. The amount of power consumed (100 liters of air/15 watts) with a collection efficiency found to be greater than 90% for particles larger than 1 micron is unparalleled performance. The minimization of consumable liquids in the collector is accomplished by dry sampling onto a tape. This biosensor will utilize an ionized gas or plasma lysis stage to open cell and spore membranes. The biological sensor approach is based on recent developments by JHU-APL to produce a miniature matrix-assisted laser desorption ionization (MALDI) mass spectrometer that rapidly (< 1 minute per sample) identifies bacteria and spores by comparison of pure cultures and simple microbial mixtures against a library of known MALDI spectra. The data along with GPS information will be relayed by RF means. This biological aerosol concentrating device will be coupled with the vapor concentrator (CBD00-107) to achieve a complete chemical and biological detector. the focus of this project is to integrate a miniature sampling system that can concentrated hazardous biologival particulate from air and rapidly identify the pathogens. These miniature samplers will be integrated into the JHU-APL MALDI mass spectrometer to provide rapid identification in a small package.

LUNA INNOVATIONS, INC.
2851 Commerce Street
Blacksburg, VA 24060
Phone:
PI:
Topic#:
(540) 953-4276
Mark Jones
CBD 00-107
Title:Field-Deployable Chemical Point Detection Network
Abstract:According to the 1999 Department of Defense Nuclear/Biological/Chemical Annual Report to Congress, "The number of nations with chemical and biological weapons (CBW) capabilities is increasing. Similarly, the sophistication of CBW capabilities is increasing. Proliferation of weapons technology, precision navigation technology, nuclear (medical, power, and industrial applications), and CBW technology to developing nations presents the United States with a complicated national security challenge." To counter the threat of chemical weapons, rapid, miniature, field deployable, detection capabilities are required. During this Phase I program, Luna Innovations, formerly F&S, Inc., and its partners propose to develop a field deployable miniature ultrasensitive system capable of chemical/biological (CB) agent detection. The Luna system will detect chemicals, such as paraoxon, a model for organophosphates like Sarin, VX, and Tabun. Through prior funding, Luna has made breakthroughs in the development of a miniature, low power, wireless, support system and patented long period grating (LPG) technologies using affinity coatings for detection of biological and chemical targets. This program will focus on integrating the LPG with a wireless support system and a commercially available microfluidic sampling system. The Luna team is both qualified and motivated to build upon their combined demonstrated abilities to develop and commercialize this revolutionary technology. Research concerning field deployable chemical/biological agent detection system will yield high-resolution, low-cost, multi compound, affinity systems for applications in 1) chemical/biological agent detection 2) drinking and wastewater monitoring, 3) large-scale, high-speed testing in the medical field, 4) chemical analysis, and 5) intelligent process monitoring of advanced materials.

OPTIMETRICS, INC.
3115 Professional Drive
Ann Arbor, MI 48104
Phone:
PI:
Topic#:
(410) 893-9714
C. Parker Ferguson
CBD 00-108
Title:Chemical Immobilizing Agents for Non-Lethal Applications
Abstract:A program is proposed to demonstrate the feasibility of innovative safe and reliable chemical immobilizing agent(s) for use in non-lethal applications for military and law enforcement situations. Previous approaches to this problem were deficient in one or more technical aspects such as low safety ratios or inadequate performance characteristics. This program will lead to a capability that does not currently exist. Various elements of DoD have expressed interest in obtaining such a capability over the years. Recent studies suggest three new agent combinations with potential for meeting user objectives. Phase I studies will consist of a Front End Analysis comprising the following elements: review existing data on the candidate agents; define scenarios of use and operational parameters; conduct range finding toxicological animal tests, and correlate results with those from previous studies. The purpose of the FEA is to determine feasibility for one or more candidates as immobilizing agents. Phase II will include human volunteer studies to correlate various physiological parameters by specific routes of administration (intramuscular and inhalation) with results from animal studies, and development of agent delivery systems. For many years national, state, and local law enforcement agencies have desired non-lethal alternatives to guns, bullets, and clubs. Success in this effort will provide enormous potential benefit to both U.S. and foreign law enforcement organizations.

ICET, INC.
916 Pleasant St., Unit 12
Norwood, MA 02062
Phone:
PI:
Topic#:
(781) 769-6064
Shantha Sarangapani
CBD 00-109
Title:A Novel Composite Fabric for CBW Deactivation and Protection
Abstract:We are proposing a nanocomposite, microporous membrane -fabric laminate with " in situ" CBW agent deactivating properties. ICET Inc has developed certain formulations with metals and stable organic compounds that show excellent biocidal activities. Our preliminary work has also shown good promise of producing a microporous membrane incorporating biocidal and chemical agent deactivating fillers. Such a membrane shows the required high moisture permeation rate while completely blocking organic simulants such as TCE and DCP. The composite membrane is flexible, thin ( 2-4mils) and very tough. During this phase I we will also examine the incorporation of the same "active" formulations onto the shell fabric by novel methods. We plan to characterize the biocidal, virucidal and sporicidal properties of the fabric and the membrane and test the permeation characteristics of the membrane as well towards water vapor and chemical agent simulants. The custom fabric/membrane laminates will be subjected to a battery of tests involving live agents and chemical agents during the phase I option period. The kinetics of hydrolysis or deactivation of CW agents and the "kill rate" of bacterial endospores and bacterial viral species will be demonstrated. Extensive non-military applications of this thin membrane which can be laminated between a variety of special fabrics, offering an invisible sheild against toxic vapors and germs are imminent. Examples are tents, boots, respirators, hospital masks, garments for HAZ-Mat operations, and suits.

TDA RESEARCH, INC.
12345 W. 52nd Ave.
Wheat Ridge, CO 80033
Phone:
PI:
Topic#:
(303) 940-2317
Silvia D. Luebben
CBD 00-110
Title:A Rubber Nanocomposite for Chemical Protective Gloves
Abstract:Many military agencies use butyl rubber gloves for handling chemical warfare (CW) agents. Butyl rubber has outstanding barrier properties against polar chemicals but readily swells in hydrocarbons, aromatic solvents, oils, and greases. Moreover, butyl rubber is very flammable. Most butyl rubber gloves are produced by solvent dipping, an expensive and pollution-creating method. The Joint Chemical and Biological Defense is interested in a new material to replace butyl rubber for the production of chemical protective gloves without the use of organic solvents. TDA proposes to develop a rubber nanocomposite to replace butyl rubber in chemical protective gloves. The rubber matrix of the composite will be a commercially available latex, and the nano-sized filler will be a proprietary reactive organic-inorganic hybrid developed at TDA. The new nanocomposite is expected to match the CW agent resistance of butyl rubber, and have better mechanical properties and higher resistance to non-polar organic solvents. TDA rubber nanocomposite will be processed by latex dipping, a solventless process, and will have excellent fire retardant properties. TDA's rubber nanocomposite will have a wider spectrum of application than today's rubbers in terms of fluid resistance. Moreover, it will be processed by latex dipping rather than solvent dipping. Becuase of these advantages, we expect TDA's material to replace butyl rubber in military and civil protective clothing . Other possible applications include seals, O-rings, oil field parts, diaphragms, belts, wire cable insulation, hoses, footwear soles, pharmaceutical closures, bottles, bladders, and liquid containers.

MATTEK CORP.
200 Homer Ave
Ashland, MA 01721
Phone:
PI:
Topic#:
(508) 881-6771
Patrick Hayden
CBD 00-113
Title:Development Of Human Skin Model For Sulfur Mustard Research
Abstract:Chemical warfare agents such as bis-(b-chloroethyl) sulfide (HD) pose a significant threat to U.S military and civilian populations. Exposure of skin to HD causes burn-like symptoms such as erythema, edema and severe vesication (blistering). To combat this threat, prophylactic and/or therapeutic interventions to HD exposure are needed. Development of such interventions requires an understanding of the mechanism of action of HD. However, a major impediment to understanding HD-induced pathogenesis is lack of an adequate experimental model of human skin. Since current models do not possess the appropriate attributes for HD research such as a complete basement membrane with dermal/epidermal adhesion structures, an in vitro human skin model for HD-related studies is needed. The purpose of the current proposal is to develop an in vitro human skin model suitable for HD research. The model will contain human keratinocytes and/or fibroblasts and will possess all morphological and ultrastructural features required for HD research. The model's response to HD or HD analogues will be investigated in terms of biochemical effects leading to blister formation. In Phase II, the model will be utilized to gain a mechanistic understanding of HD induced vesication and to investigate prophylactic and/or therapeutic interventions to HD exposure. In addition to providing a model which will greatly facilitate sulfur mustard vesication studies, this work will lead to a full thickness skin model which will allow the study of numerous dermis-based skin phenomena such as photoaging, photodamage, wound healing, and cancer progression. This improved tissue model will be useful to the cosmetic and pharmaceutical industry in irritancy and efficacy testing of their new products.

NANOMATERIALS RESEARCH CORP.
2620 Trade Center Avenue
Longmont, CO 80503
Phone:
PI:
Topic#:
(303) 702-1672
Tapesh Yadav
CBD 00-114
Title:Solventless Reactor for the Destruction of Chemical Warfare Agents and Toxic Materials
Abstract:There is a need for a reliable technology to neutralize chemical warfare agents and toxic chemicals for both military and civilian applications given the increasing threat of chemical warfare by terrorists or accidental release of toxic chemicals. There is particular interest in technologies which can be used to neutralize containers or shells contaminated with chemical agents or toxic chemicals. Advances in metal oxide chemistry suggest that nanoparticulate metal oxides may be utilized for these purposes. Nanomaterials Research Corporation (NRC) will, during Phase I, develop nanoparticulates for the destruction of chemical warfare agents and demonstrate the proof-of-concept of a mobile reactor that can be used to treat contaminated containers or shells before relocation. Phase II will further develop, optimize and test the technology. Phase III will commercialize the technology. Potential applications include an effective and reliable neutralization of chemical agents and toxic chemicals after accidental or intentional release. Peace time military applications include benign storage and handling of chemicals. Commercial applications include neutralization of toxic chemical release and a technology for controlling contamination/hazards for occupational safety of production personnel.

NANTEK, INC.
1500 Hayes Drive
Manhattan, KS 66502
Phone:
PI:
Topic#:
(785) 537-0179
Kenneth J. Klabunde
CBD 00-114
Title:Chemical Destruction of Chemical Warfare Agents and Toxic Materials in a Mobile Solvent-free Reactor Based on Reactive Nanoparticle Technology
Abstract:The objective of this Phase I proposal is to develop a solvent-free mobile reactor system capable of chemically destroying 4-6 L of chemical warfare agents and toxic materials. Nantek's reactive nanoparticle technology has demonstrated excellent results for ambient and elevated temperature decompositon of hazardous chemicals including warfare agents. Building on this research and success, Nantek proposes development of a closed-system reactor utilizing reactive nanoparticles as decomposition agents to address the need for a mobile, highly efficient decontamination system. During Phase I, Nantek will develop and optimize a laboratory-scale closed-system reactor based on its highly reactive nanoparticle materials for the complete destruction of a range of warfare agents including chlorinated hydrocarbons, organophosphorus compounds, and nerve and blistering agents. During Phase I, nanoparticle formulations will be identified and system conditions optimized to deliver complete (>99.99%) decomposition of mimics of warfare agents. In addition, a preliminary design of a full-scale reactor will be completed during Phase I. Follow-on research will focus on final design, optimization, and testing of a full scale prototype reactor with both mimics and actual warfare agents. Successful completion of this research will lead to the development of mobile reactor systems to address critical needs for the decomposition of hazardous chemicals in both military and civilian applications. Such a system could potentially provide on-site remediation of hazardous chemicals thereby limiting hazards associated with transport of highly toxic materials for off-site destruction or storage.

INNOVATIVE SURVIVABILITY TECHNOLOGIES
P.O. Box 1989
Santa Barbara, CA 93116
Phone:
PI:
Topic#:
(805) 692-2505
Frank Swanson
CBD 00-201
Title:Low Cost Projectile Dispersed Chemical Detector
Abstract:Infrared spectroscopy is an accepted, high accuracy technique for measuring the concentrations of vapor species in the atmosphere. Large, heavy, expensive laboratory instruments use a grating to measure details of the absorption spectra. Commercial instruments use non-dispersive infrared spectroscopy (NDIR) with two narrow line filters the concentration of one specific gas species. MEMS technology allows the combination of a light source, chopper, filter and detector into one chip for NDIR measurements, reducing parts count, cost, and complexity while increasing ruggedness and reliability. The transition of MEMS technology into the chemical detection arena represents a major advantage for remote sensing of the chemical environment for both DoD and commercial applications. Remote sensing is only good if it can be accomplished without jeopardizing personnel during placement of the sensors. This project not only demonstrates the feasibility of detecting chemical agents with a MEMS gas detector, but also presents a ruggedized design that can be used to place the detectors into a potential hostile environment by shooting them out of a 5-inch gun or 120mm mortar. These ruggedized chemical detectors can be used for a number of commercial applications as well as military. If for instance, there is a need to examine the environment around a hazardous chemical spill, these detectors can be launched into the area without jeapardizing personel and obtain information about the chemical toxins in that area. There are many other benefits that these types remote sensing can provide.

CREARE, INC.
P.O. Box 71, Etna Road
Hanover, NH 03755
Phone:
PI:
Topic#:
(603) 643-3800
Marc A. Kenton
CBD 00-202
Title:Miniature Gas Sampling System for Chemical Monitors
Abstract:Advancing the military's ability to counter chemical and biological threats represents an intense area of ongoing research and development. Substantial advances have been made in miniaturizing chemical and biological agent detectors and support electronics. By contrast, the associated gas sampling systems remain unacceptably large, heavy, and power-hungry. This situation compromises efforts to produce highly portable chemical dosimeter/detectors for personal and distributed area monitoring. Creare proposes to develop an advanced, compact gas sampling system as an enabling technology for the deployment of such monitoring devices. Phase I efforts will focus on a proof-of-concept demonstration of an innovative miniature air pump with maximum dimensions of 51x76x10 mm (2x3x3/8 in) and weighing less than 100 grams (3.5 oz.). Attributes of the proposed pump include high efficiency, non-pulsating flow, and extremely low noise and vibration. In Phase II, a prototype of a complete, optimized gas sampling system will be developed. This system will feature variable flow and pressure capabilities and integral flow switching valves. The proposed work plan benefits greatly from recent Creare work on miniature vacuum pumps and liquid pumps for terrestrial and space applications, as well as Creare's 20 year history of developing and building miniature turbo-pumps for NASA and DoD applications. Completion of this development project will facilitate the widespread use of personal chemical dosimeter/detectors among DoD components deployed in high risk areas. This will greatly improve the reliability of detection of chemical threats, particularly in situations where personnel are widely dispersed. Assessment of the severity of any personal exposure to chemical weapons will be rapid and highly accurate, such that appropriate protective measures can be employed in time to avoid debilitation and possible loss of life. Records of time-weighted exposure data will be invaluable for effective follow-up medical care and long term effects evaluations. Abundant commercial applications exist for an improved gas sampling system for portable analytical instruments including industrial dust and vapor monitors, gas chromatographs, mass spectrometers, etc. Effective industrial hygiene programs and studies of the personal effects of ambient air quality will be facilitated by the availability of sophisticated, self-contained "clip-on" monitoring devices. This DoD technology development will also have applications in hazardous gas monitors for firefighters, law enforcement officers and chemical hazard response teams.

MESOSYSTEMS TECHNOLOGY, INC.
3200 George Washington Way
Richland, WA 99352
Phone:
PI:
Topic#:
(509) 375-1111
Yin-Fong Su
CBD 00-203
Title:Development of a Portable Aerosol Collector
Abstract:MesoSystems Technology, Inc. proposes to design, build, and test a novel miniature electrical aerosol collector to capture particulate on miniature structures. The novel miniature electrical aerosol collector will sample large volumes of air to concentrate the biological entities onto an aerogel-coated microstructure surface using electrical and inertial forces. After the soldier's mission, the collection fluid is added either to: dissolve the aerogel and provide a biological sample or change the properties of the aerogel coating on the microstructure to release the biological material for detection. The coin-sized device draws air from a soldiers' surrounding environment with a battery-powered minimal power-consuming fan. The impaction efficiency of greater than 90% for particles onto the aerogel-coated microstructures was predicted by computational fluid dynamic (CFD) modeling. While the impaction collection efficiency is expected to be large, the inclusion of electrical collection mechanisms allows for even higher capture efficiencies. These aerosols are charged (without lysing the cells or other biological entities) by an upstream innovative electrode design that simulates high frequency fields using a simple battery-powered low voltage approach. The microstructure approach to collection fabricated with microinjection manufacturing techniques allows a disposable device to be made with an exceptionally high collection efficiency. Rapid collection of aerosols of biological orogin from air for sample identification.

TECHNISPAN LLC
1133C Greenwood Road
Pikesville, MD 21208
Phone:
PI:
Topic#:
(410) 602-9007
Glenn E. Spangler
CBD 00-204
Title:Ultra-fast Cemical Agent Detector with Fast Gas Chromatograph (CG) Analysis
Abstract:An ion mobility spectrometer (IMS) with a discharge ionization source will be coupled to a gas chromatographic (GC) column for fast gas chromatograph analyses. Provide a fast GC/IMS capability with a selectivity better than GC or IMS alone.

INNOVATEK, INC.
350 Hills Street, Suite 104
Richland, WA 99352
Phone:
PI:
Topic#:
(509) 375-1093
Patricia M. Irving
CBD 00-205
Title:Cyclone Separator for Bioaerosol Sampling
Abstract:InnovaTek proposes to design, fabricate, and test a particle separation system that uses cyclonic forces to separate and remove large particles from an airstream and concentrate small particles for sensor/detector technology. Our approach will use micro-fabrication and microfluidic techniques to accomplish the objectives. Computational fluid dynamics (CFD) modeling will be used to design a novel two-stage multi-cyclone system operating in parallel to achieve a high flow rate device that will separate particles at the desired size ranges. The capability to miniaturize systems provides a significant advantage in the development of aerosol separation technology by allowing the development of products that have low power requirements, are lightweight and portable. The results from this work will lead to a novel, portable, multi-functional device that is suitable for pathogen separation and collection in field situations. Threats from microorganisms in the air as a result of natural phenomena or human-induced activities such as terrorism cannot be adequately monitored and evaluated with current technology. Early warning, hazard recognition, personal protective equipment, exposure evaluation, and environmental monitoring are needed to prevent and reduce impacts from airborne infectious, toxic, or genetically modified material. Monitoring of air quality is an important public health need. Commercial success in meeting these needs depends on the development and demonstration of an inexpensive real time device that is small and uncomplicated from an operator's perspective. The proposed integrated device is expected to be in high demand from a wide variety of global scale markets, including defense markets and emerging commercial markets such as public health and food safety.

LYNNTECH, INC.
7610 Eastmark Drive, Suite 202
College Station, TX 77840
Phone:
PI:
Topic#:
(409) 693-0017
Craig C. Andrews
CBD 00-206
Title:Detection of Chemical and Biological Hazards in the Field
Abstract:It is extremely difficult to detect and discriminate the presence of dangerous chemical and biological weapons in the field. The usual way to identify a biological or chemical threat is to manually sample the suspected material, transport it to a secure laboratory, and perform standard laboratory analysis. This is a dangerous, expensive, and time-consuming process. Technologies capable of identifying potentially hazardous biological entities in the field are needed urgently. This proposal concerns the development of a potable mass spectrometer unit that is uniquely able to detect both chemical and biological hazards. The benefit of this analytical method is that it can analyze substances directly i.e., there are no reagents involved. In addition, the method is rapid and automated. The Phase I approach is to integrate a new sample preparation method, combined with new chemometric software, into a self-contained potable mass spectrometer. Performance will be assessed using selected surrogates for both chemical and biological agents. Included in the study will be engineering factors related to safe operation without exposure of the operator to hazardous materials. Lynntech Inc., will provide all the skill sets required to carry out this project including: design and assembly of mass spectrometry hardware, testing using chemical and biological surrogates, and the use of chemical analysis software. The aim is to develop a mass spectrometry system in a final (pre-production) configuration by the completion of Phase II. As an existing manufacturer of analytical/electronic equipment, Lynntech, is well positioned to further commercialize the technology. The company has the capability to manufacture multiple production units at our in-house production facility. Lynntech's management team is experienced in obtaining private sector funding for further technology commercialization (e.g. through strategic partnerships). In addition to military uses, the resulting technology has numerous uses in the private sector including: monitoring industrial effluents, food safety analysis, medical diagnostics, and air quality monitoring, etc.

SCENTCZAR CORP.
213 Taylor Street
Fredericksberg, VA 22405
Phone:
PI:
Topic#:
(540) 372-2004
Dr. Joseph E. Roehl
CBD 00-207
Title:Miniature Passive Indicator (MPI) for MOPP Garment Degradation Indication
Abstract:MOPP garments are designed to be permeable so that a soldier can operate effectively in MOPP gear while expending great energy over relatively long periods of time. Embedded charcoal systems are used to absorb chemical agents while allowing the garment to breathe. A major concern with these systems is that the charcoal will load with common battlefield materials and cease to be effective at absorbing chemical warfare agents. In addition it is possible for the MOPP ensemble to become physically damaged. Scentczar Corporation's Miniature Passive Indicator (MPI) will allow soldiers to check their MOPP ensemble for effectiveness periodically. The System will be packaged with the MOPP garments during manufacturing so that accidental degradation during storage can also be determined. When a soldier first unpacks the garment he/she can check it using the MPI already in the package and then periodically throughout the mission. Phase I of this study will modify a Scentczar developed passive indicator badge and reader system, already under development, for se in the Marine Corp application. Phase II will field an entire prototype system which will be tested in the field. he MPI will save military and commercial filtering system users significant amounts of money by allowing them to change out filters only when they are degraded rather than on a fixed time schedule. Example systems include gas mask filters, collective protection filters on ships and field shelters, and clean room filters.

COHERENT TECHNOLOGIES, INC.
655 Aspen Ridge Drive
Lafayette, CO 80026
Phone:
PI:
Topic#:
(303) 604-2000
Timothy J. Carrig
CBD 00-301
Title:Compact, eyesafe, multi-function coherent lidar for discrimination of biological agents
Abstract:A portable, eyesafe multi-spectral lidar system for remote detection and tracking of bioaerosol clouds is proposed. The sensor will provide volumetric range-resolved wind velocity and aerosol concentration measurements to ranges of several kilometers. The backbone of the sensor is a pulsed SWIR coherent Doppler lidar that has been demonstrated as able to detect and track bioaerosol simulant plumes. This existing technology will be augmented with the ability to transmit and receive arbitrarily polarized light to enable studies of the polarization properties of bioaerosol clouds. In Phase I, CTI will collect and review data regarding the polarization properties of bioaerosols. Sensor performance modeling will then be conducted to establish the sensitivity and spatial and temporal resolution capability of a polarization sensitive coherent transceiver. An existing 2 micron WindTracer lidar will then be modified to allow field validation of our model. A growth path to a frequency-agile MWIR-LWIR differential scattering (DISC) and differential absorption lidar (DIAL) will also be provided. This will provide additional ability to discriminate aerosol and tracer gas clouds. The proposed technology development path is aimed at the Phase II demonstration of a unique multi-function biosensor and the Phase III deployment of a compact, user-friendly groundbased or airborne multi-function chem/bio sensor. Applications include tactical surveillance for chem/bio defense, battlefield smoke and cloud transport and structure model development and validation, fence-line monitoring of industrial facilities, turbulence statistics and turbulent transport modeling for meteorological research, and airport terminal area weather surveillance.

SCHWARTZ ELECTRO-OPTICS, INC.
3404 N. Orange Blossom Trail
Orlando, FL 32804
Phone:
PI:
Topic#:
(407) 298-1802
Valey Kamalov
CBD 00-301
Title:Discrimination of Biological Agents at Standoff Distances
Abstract:During Phase I, SEO will carry out experimental measurements of backscattered light for aerosol cloud of Bacillus globigii (BG), growth media, and kaolin particles. First parameter to be evaluated is the depolarization ratio. The theoretical calculations support the possibility of discrimination of bioparticles based on polarization properties. Second parameter to be evaluated is a circular dichroism (CD) of backscattered signal. Technically, circular polarized (left/right) laser light will be transmitted to carry out those measurements. Backscattered light will be detected, and the ratio of signal intensities for left- and right-circular polarized excitation will be recorded. Third, we will measure an off-axis contribution into backscattering signal by varying the opening of the diaphragm in front of the detector. Here, we first have to find out, whether a multiple scattering will be reasonably high for the realistic concentration of bioparticles. If so, we will carry out an experimental measurements for the clouds and build a multiple scattering model to characterize and discriminate the biological particles. The goal of Phase I is to get solid experimental data for aerosol cloud of biological/nonbiological particles, and make a conclusion - which of proposed techniques (depolarization, CD, and off-axis) works best. Based on the best choice, SEO will design characteristics and project performance of eye-safe man portable lidar to be build during Phase II. The successful development of polarization and/or multiple scattering techniques for the discrimination of biological agents will reduce the probability of false alarm.

LYNNTECH, INC.
7610 Eastmark Drive, Suite 202
College Station, TX 77840
Phone:
PI:
Topic#:
(409) 693-0017
Anthony Giletto
CBD 00-302
Title:A Hand-Held, Lightweight, and Compact System for In-Flight Decontamination
Abstract:The Air Force needs a hand-held, lightweight, and portable decontamination system that can efficiently decontaminate contaminated cargo and equipment in confined spaces during flight. Although many decontamination systems exist, no system meets all of the criteria of an ideal in-flight decontamination system. The ideal system would be one that easily dispenses a decontaminant that is capable of decontaminating all known stockpiled chemical and biological threats, compatible with cargo materials, safe to handle by the user, and environmentally friendly. Lynntech has developed an innovative reactive water-based formulation that can rapidly decontaminate HD, GB, and VX in minutes. The formulation is also very effective against an Anthrax spore surrogate. The formulation has undergone significant development in our laboratory over a period of three years and its capability to kill Anthrax spores is currently being evaluated. In this proposal, we propose to package the formulation into a foam that can be dispensed through a modified AFFF fire extinguisher. Although the technology incorporates some highly advanced chemical processes, we intend to exploit the fact that the formulation is remarkably simple to use. Chemical and biological decontamination technologies are requested by numerous entities including local law enforcement, customs agents, firefighters, and emergency medical response personnel. Thus, the technology has numerous non-military uses.

TRITON SYSTEMS, INC.
200 TURNPIKE ROAD
Chelmsford, MA 01824
Phone:
PI:
Topic#:
(978) 250-4200
Bryan Koene
CBD 00-303
Title:Flexible Chemical and Biological Agent Resistant Nanocomposite Materials for Mask Hoods and Water Containers
Abstract:Triton Systems proposes to combine its innovative polymer-clay nanotechnology with chemically resistant polymers to develop revolutionary flexible nanocomposite materials that will provide significant performance improvements for chemical and biological (CB) defense gear such as mask hoods, mask components, and water Our innovative approach will produce materials for these applications that have superior CB resistance than the currently used materials to provide unilateral protection in support of our soldiers. This will allow a thinner barrier material to be used, reducing the weight of the components as well the cost. This proven nanotechnology has already shown increased chemical, flame, and abrasion resistance in various polymer matrices. containers. This successful Phase I will develop an enabling technology that will benefit many areas where chemical agent resistance and/or flammability are required. These materials may also be applied to other programs requiring protective clothing and gear such as firefighter or first response personnel.

ENTROPIC SYSTEMS, INC.
P.O. Box 397
Winchester, MA 01890
Phone:
PI:
Topic#:
(781) 938-7588
Robert Kaiser
CBD 00-304
Title:Open Wound Decontamination
Abstract:The capability to decontaminate (preferably neutralize, but at least remove) chemical and biological agents in open-wounds of casualties is extremely valuable to the military. This capability will increase the safety and survivability of casualties and personnel in the course of medical treatment of casualties in an environment that is contaminated with chemical and/or biological threat agents, as well as allow medical personnel to more readily treat casualties in a safe and effective manner. The technology needs to be rapid but mild due to the sensitive nature of open-wounds. The decontamination of a patient with an open- wound is a multi-faceted problem that involves both personal decontamination by the wounded individual, and casualty decontamination by medical support personnel. The principal objectives of the proposed Phase I program are to: a. Demonstrate, with simulants, the feasibility of a novel method of decontaminating an open-wound that should be effective with a broad range of CWA, and that would be simple and light enough to be used as a method of personal decontamination. b. Develop a patient decontamination procedure that would be less time consuming, but just as safe, than the current method specified in Appendix C of FM 8-10-7. Personal Decontamination: The Phase I effort will provide the technical data needed to establish the viability of a novel means of personal decontamination that would be effective against a broad range of agents. This product offers many possibilities for improved wound treatment, not the least is the ability to adsorb therapeutic or bacteriostatic agents onto a material that otherwise would behave as a normal gauze bandage. Casualty Decontamination: The Phase I effort will provide the technical data needed to compare the efficiency and effectiveness of a proposed spray decontamination approach to the current method now being used. It will also provide a preliminary design of a prototype field decontamination module that would be built and tested in Phase II. Potential users of this equipment are projected to include hospitals, fire departments, and manufacturers and distributors of toxic chemicals