---------- CBD ----------

22 Phase I Selections from the 05.1 Solicitation

(In Topic Number Order)
ARGONIDE CORP.
291 Power Court
Sanford, FL 32771
Phone:
PI:
Topic#:
(407) 322-2500
Mr. Fred Tepper
CBD 05-102      Selected for Award
Title:Nano Alumina Air Filtration Media
Abstract:NanoCeramr filtration media has been developed for purification of water. The active component is a nano alumina fiber only 2 nanometers in diameter. When dispersed with microglass fibers as part of a non-woven fibrous filter it is capable of retaining sub-micron and nanosize particles smaller than virus while maintaining a high flux. Such media has a dirt holding capacity tens of times greater than microglass, meltblown or membrane media, as well as a high filtration efficiency. The media is now being manufactured at a high rate using paper making technology. Pleated cartridges are now being marketed as a high performance turbidity filter. Multilayer depth media versions are being developed for portable as well as residential microbial water filters. Adaptation of the media for air filtration is proposed. Preliminary data show the media is capable of capturing a high level of virus containing aerosols. Initial DOP and NaCl tests show a retention exceeding 99%. During Phase I we will reduce pressure drop to that of HEPA media, while exceeding 99% retention of aerosolized 1m latex spheres, 0.2m DOP liquid and E coli bacteria. In Phase II we will develop a low pressure drop substitute that exceeds HEPA's performance.

AGENTASE LLC
3636 Boulevard of the Allies, Suite B-17
Pittsburgh, PA 15213
Phone:
PI:
Topic#:
(412) 209-7402
Dr. Markus Erbeldinger
CBD 05-103      Awarded: 18MAY05
Title:Decontamination Assurance Spray
Abstract:There are many products that can identify chemical weapons. They range in complexity from simple colorimetric chemical test strips or gas tubes, to more complex multi-step test kits, to intricate arrays of gas chromatographs and mass spectrometers. None of the products is specifically designed to illustrate the presence of chemicals on surfaces or have use as a decontamination assurance method. The proposed decontamination assurance spray will benefit end-users in the homeland security and military communities as a dispersible sensing technology that validates remediation of critical resources after a chemical event. The proposed technology has an extremely low logistical burden and can be easily used by first responders. It is based on our patented biocatalytic polymer synthesis and sensing technologies. It will retain attributes of the present nerve agent sensor, which detects nerve agent contamination using two enzyme reactions in dynamic equilibrium with each other. The existing sensor performs well, with response times of seconds, sensitivity on the order of parts per billion, and great resistance toward interference. The sensor outperforms any conventional technology for nerve agent detection with its ease of use, interference resistance, broad-based compatibility with surfaces, liquids, and gases, and low cost.

TDA RESEARCH, INC.
12345 W. 52nd Ave.
Wheat Ridge, CO 80033
Phone:
PI:
Topic#:
(303) 940-2341
Dr. Brian Windecker
CBD 05-104      Awarded: 10MAY05
Title:New Materials for Smart Fabric Chemical Agent Sensors
Abstract:Defense against chemical weapons is a critical DoD requirement. An effective defense requires the development of a combination of unique clothing systems that provide a physical barrier to toxic vapors, liquids, and aerosols, as well as a system to detect chemical threats. Protective clothing and detection systems currently exist, but ideally the detection equipment should be miniaturized and integrated into to the clothing. A straightforward concept for developing a "smart cloth" uniform with built-in detection sensors is to incorporate small sensors into existing fabrics. These sensors would be lightweight, flexible, durable and highly sensitive to detect the agents of interest. They would also ideally communicate with the other sensors in the area and be compatible with other similar forward-deployed sensors. Such a sensor laden smart-fabric would benefit the DoD by reducing the weight burden and logistics of providing combination clothing and sensor systems, thus eliminating the need to carry larger sensor equipment. In this Phase I SBIR project TDA Research, Inc. will develop and test new sensor materials needed to make these smart cloth chemical agent sensors a reality.

QUANTUMBIO, INC.
200 Innovation Blvd, Suite 261
State College, PA 16803
Phone:
PI:
Topic#:
(814) 235-6908
Lance Westerhoff
CBD 05-106      Awarded: 13MAY05
Title:In Silico Screening for Biothreat Countermeasures
Abstract:The current state of the art of in silico drug discovery or computer aided drug discovery relies almost exclusively on molecular mechanics force fields, such as AMBER and CHARMM, and empirical potentials. It is well known that while these approaches are excellent for certain applications, they have thus far proven less then satisfactory for thorough understanding the interactions of enzyme-inhibitor systems when used in Ki or IC50 prediction and best pose selection. To address this issue, in the first part of the proposed research, we will utilize our linear scaling, quantum mechanics algorithm and collaborate with our industrial partners to further research, develop, and validate a quantum mechanics-based score function, called QMScore, capable of predicting Ki and binding modes to the levels of accuracy required by the in silico drug discovery world. In the second part of the project, we utilize a knowledge management and artificial intelligence platform to aide in the usability of this advanced methodology by researching the relationships between structure and QM convergence - the ultimate goal being the development of an intelligent and adaptive system for drug discovery.

REDONDO OPTICS, INC.
2803 Faber Street
Redondo Beach, CA 90278
Phone:
PI:
Topic#:
(310) 292-7673
Dr. Edgar A. Mendoza
CBD 05-107      Awarded: 13MAY05
Title:Continuously Variable Attenuated-Phase-Shifted Photomask for Integrated Spectroscopic Sensor Platforms enabled by Optical Nanolithography
Abstract:Redondo Optics Inc. (ROI), a world leader in engineering and manufacturing of leading-edge nano-materials, optical sensors, fiber and integrated optics, and advanced photonics instrumentation proposes to develop and demonstrate for the first time the concept of an etch-less, deep-UV, fully continuously variable attenuated-phase-shifted mask (ConvaPSMT) technology to enable ultra-high resolution, optical nanolithography techniques for the cost effective production of integrated terahertz-frequency spectroscopic chemical and biological sensor platforms. The ConvaPSMT technology can be produced on quartz, fluorinated quartz, or calcium fluoride substrates to produce a continuously variable attenuated-phase-shifted photomask that allows the lithographic production of ?100-nm features using conventional contact or projection aligners or state-of-the-art interferometric lithography (IL), interferometric imaging lithography (IIL), or liquid immersion lithography (LIL) systems. This proposal addresses the problem of facilitating a higher resolution and higher throughput capability by improving the structure of phase-shift masks used to produce biological and chemical integrated spectroscopic sensor platforms using next generation nanolithography techniques. The ConvaPSMT technology will readily find uses in the military, government, and commercial sectors for applications in nanoelectronics, photonics, molecular electronics, spintronic, microfluidic, or nano-mechanical (NEMS) technologies.

METSS CORP.
300 Westdale Avenue
Westerville, OH 43082
Phone:
PI:
Topic#:
(614) 797-2200
Dr. Kenneth Heater
CBD 05-108      Awarded: 09MAY05
Title:Portable System for Immediate Decon of Interior Spaces
Abstract:Under the current SBIR solicitation, the DoD is interested in the development of novel decontaminating materials and methods to support rapid decontamination of interior spaces contaminated with chemical and biological agents. The proposed system should be portable, lightweight, self-powered and easy to use so it can be readily transported. The intended use of the portable system is to support (operational) decontamination procedures in the field so US forces can operate in treated spaces with a minimum level of protective equipment. METSS proposes to address this need through the development of a novel decontaminating emulsion that can be applied using a conventional pressurized sprayer and/or fire extinguisher without requiring post-decontamination cleanup operations. The proposed approach will build upon recent commercial developments in fire suppression materials and recent advances in chemical and biological decontamination chemistries, yet rely on familiar delivery methods that have been used for years to extinguish fires by both trained and untrained personnel.

TDA RESEARCH, INC.
12345 W. 52nd Ave.
Wheat Ridge, CO 80033
Phone:
PI:
Topic#:
(303) 940-2355
Dr. William L. Bell
CBD 05-108      Awarded: 10MAY05
Title:Transportable System for Immediate Decon
Abstract:Surfaces and enclosed spaces (such as vehicle crew compartments) that are contaminated with chemical warfare (CW) or biological warfare (BW) agents must be rapidly decontaminated to allow continued operations. Unfortunately, all of the current decon technologies have significant disadvantages, such as excessive weight, bulk, cost and complexity, limited storage stability, and a need for hazardous materials that cannot be readily transported. Some current technologies are effective against either CW or BW agents, but not both; others are effective on surfaces or in decon of enclosed spaces, but not both. There is no easily transported, integrated system that is active against both CW and BW agents and effective both on surfaces and in enclosed spaces. TDA Research, Inc. (TDA) proposes to develop an inexpensive, compact system for immediate decon of both surfaces and enclosed spaces that is active against both CW and BW agents. TDA's system uses materials that are stable on storage and readily transported by air. It is readily operated and produces no hazardous residue. In Phase I TDA will conduct laboratory and field tests to demonstrate the feasibility of the system, and an engineering analysis to estimate its size and cost in production.

TORCH TECHNOLOGIES, INC.
2227 Drake Avenue, Suite 27
Huntsville, AL 35805
Phone:
PI:
Topic#:
(256) 319-6000
Mr. Mike Muratet
CBD 05-110      Selected for Award
Title:Critical Data Processing for Chemical Warfare Simulant Field Testing - Advanced Data Fusion
Abstract:To properly measure (and understand) the performance of a standoff detector, properties of the challenge cloud must be known. Meteorological models, such as HPAC and VLSTRACK, have proven to be reasonably good tools for predicting cloud properties. However, a problem with these tools is that they deliver ensemble averages and may not describe a specific cloud to the detail required. The Dugway approach is to use several suites of analytical instruments (point detectors, infrared imagers, spatially scanning FTIRs, and line-of-sight FTIR) to best measure cloud parameters and test conditions. A problem arises because each referee system measures differing parameters at various sensitivities, which makes determining the "best" cloud parameters complicated. Data obtained can include CL (concentration path length), average concentration, cloud width, length, height, and cloud centroid. What is needed is to use the measured data as feedback to a cloud model, so that a truly representative description of individual clouds can be developed and allow more accurate correlation of detector measurements to the current and future properties of the cloud. This would not only allow a better assessment of detector performance, but would also allow correlation of the detectors performance to real world operational needs (example, correlating Dugway Proving Ground [DPG] performance for a Battery attack at 5 km to expected performance in Baghdad). The contractor should produce a software package that will run a met model, predict referee responses, calculate a figure of merit, and rerun the met model with varying parameters to minimize this figure of merit. The software should be configurable and useable by both the Army's and DPG modeling and simulation program and be consistent with their protocols. In addition, the software output should be formatted in a manner compatible with the Army's Future Combat Systems protocol (TENA). There are inherent advantages for using existing meteorological models due to their application across a wide group of users and virtual platforms - however; original pure approaches are also encouraged. PHASE I: Provide a feasibility of technical approach and proof of process using previously collected field data. PHASE II: Produce a software package that will run a model, predict referee responses, calculate a figure of merit, and iteratively run the model with varying parameters to minimize this figure of merit. PHASE III: This software package will produce data that can be used to be used in future distributed tests, where real chemical and biological releases can be inserted.

ORONO SPECTRAL SOLUTIONS, INC.
20 Godfrey Drive
Orono, ME 04473
Phone:
PI:
Topic#:
(207) 581-3358
Mr. Luke D. Doucette
CBD 05-111      Awarded: 16MAY05
Title:Autonomous, Unattended, Reagentless Biological Agent Detector
Abstract:The goal of this project is to investigate the feasability of a unique sampling method that will lead to the development of a reagentless infrared (IR) based BW agent detection system. The current JPBDS uses lateral flow immunoassay technology as the final step in detecting bioagents, and has a detection limit of 10^5 spores/ml[ref 1]. Preliminary data from our infrared approach indicates a minimum detection limit of 1-2 orders in magnitude lower than these hand held assays. In collaboration with the JSAWM program, we are developing an IR spectroscopic method for chemical agent detection. Clearly there is an attraction for using the same platform for chemical and biological agent detection. The challenge for realization of an IR based bio-detection system is to develop the sampling methodology that will enable concentration of aerosol and water based BW agents in order to achieve the high sensitivity and speed of response.

MANNING APPLIED TECHNOLOGY
419 South Main Street, PO Box 265
Troy, ID 83871
Phone:
PI:
Topic#:
(208) 835-5402
Dr. Christopher Manning
CBD 05-112      Awarded: 12MAY05
Title:Handheld Photoacoustic Chemical Agent and Toxic Industrial Material Detector
Abstract:Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. The vision is to combine, for the first time, a preconcentrator with a photoacoustic detector that uses high- sensitivity MEMS microphone. A novel field-widened interferometer will provide high throughput from a high-efficiency infrared source. A computer-machined aluminum housing and COTS handheld computer complete the system. Dr. Pedersen will demonstrate a new approach to MEMS microphone design. Dr. Manning, the Principal Investigator, is an internationally recognized FT-IR spectrometer design expert. Military uses of the technology include a variety of sensing activities for personnel protection and monitoring of asymmetric attacks. Commercial applications include a wide range of process and quality control, medical, environmental monitoring, laboratory research, field measurements and remote sensing applications. Conservative estimates indicate a $40 million per year market for the technology. The low cost insures that it will capture a significant market share. ATK/MRC will provide Phase I, II and III support.

METSS CORP.
300 Westdale Avenue
Westerville, OH 43082
Phone:
PI:
Topic#:
(614) 797-2200
Dr. Kenneth Heater
CBD 05-113      Selected for Award
Title:Decontamination of Biological Warfare (BW) Agents, Toxic Industrial Chemicals (TICs) and Toxic Industrial Materials (TIMs)
Abstract:The US Government has spent hundreds of millions of dollars developing decontamination capabilities to protect our military personnel and equipment from chemical warfare agents. With much of the traditional research and development efforts within focused on decontamination of chemical warfare (CW) agents, there has been a recent shift in the research base to include biological warfare (BW) agents, toxic industrial chemicals (TICs) and toxic industrial materials (TIMs). With so many resources already invested in previous and ongoing research to develop safe and effective decontaminating materials for chemical warfare agents, the logical place to start when considering the decontamination of new and emerging threats is the existing body of research related to chemical decontamination being funded by the various Government agencies that are active in this community. The objective of the current solicitation, and the thrust of this proposal, is to evaluate the existing body of research being conducted within the chemical defense community to identify technologies capable of supporting the growing spectrum of decontamination needs. The proposed program will help establish the foundation needed to support the development and implementation of a single, general purpose decontaminating material or solution.

METSS CORP.
300 Westdale Avenue
Westerville, OH 43082
Phone:
PI:
Topic#:
(614) 797-2200
Dr. Kenneth Heater
CBD 05-114      Selected for Award
Title:Reducing the Weight and Volume of Peroxide-Based Decontaminant by using a Solid (Vice Liquid) Component for Hydrogen Peroxide
Abstract:Several new generation chemical and biological (CB) decontaminants are based on hydrogen peroxide (H2O2) chemistry. These new decontaminants have many desirable characteristics, including reactivity toward a broad spectrum of CB agents and toxins, as well as being less corrosive and more environmentally friendly than conventional decontaminating materials. However, these systems are still liquid based and will require significant logistical support and resources to implement in the field. Furthermore, hydrogen peroxide is reactive and temperature sensitive, so the peroxide content of formulated liquid-based systems will have to be replenished after several years. The logistics and stability issues associated with implementing hydrogen peroxide-based decontaminants create significant drivers to develop dry solid formulations that can be mixed in the field with available sources of water (including fresh water, salt water and non-potable water) to generate hydrogen peroxide. Assuming a hydrogen peroxide concentration of 8% by volume, conversion of these new decontamination systems to a solid format is estimated by the sponsoring agency to reduce the volume of decontaminant material that must be moved forward by 30-40%. Under the proposed effort, METSS will identify and characterize available sources of solid materials that can be used to formulate peroxide-based decontaminants. The evaluation will include primary peroxide generators as well as chemical additions and buffering materials known to enhance peroxide-based chemical destruction processes.

METSS CORP.
300 Westdale Avenue
Westerville, OH 43082
Phone:
PI:
Topic#:
(614) 797-2200
Dr. Kenneth Heater
CBD 05-115      Selected for Award
Title:Blending of Aircraft Washing/Cleaning Detergents and Chemical/Biological (CB) Warfare Agent Decontaminants for a Dual-Use Application
Abstract:Under the current SBIR solicitation, the DoD is interested in the development of novel decontaminant solutions based on existing aircraft approved fluids (e.g., cleaning or deicing fluids), and application methods that will be compatible with the Transportable Decontamination System (TDS). The aircraft decontaminating solution should be capable of detoxifying chemical warfare (CW) agents, Non-Traditional Agents (NTAs) and Toxic Industrial Chemicals (TICs) without adversely affecting the performance, properties or appearance of aircraft materials or increasing susceptibility to corrosion. The decontamination and cleaning solution should decontaminate, degrease, clean and protect aircraft in an environmentally friendly, cost-effective, and health and safety conscience manner. The cleaning process must be thorough and rapid to protect military personnel and avoid interference with military operations. The cleaner must also be effective under a wide variety of environmental conditions, with operational decontamination capability from -25 to 130 F. Under the proposed program, METSS will demonstrate materials and methods needed to develop a novel surface cleaner that will decontaminate as well as protect military aircraft from corrosion. The basic approach presented in this proposal will encompass the development of an advanced emulsion system that will support cleaning (dissolves the toxins) and decontamination (destroys the toxins), while providing immediate and residual substrate protection (prevents corrosion).

NEUPHARMA, INC.
513 Central Avenue, 5th Floor
Chicago, IL 60063
Phone:
PI:
Topic#:
(312) 355-4857
Dr. James Auta
CBD 05-116      Awarded: 17MAY05
Title:Imidazenil: A Protective Agent Against Chemical Warfare Agents induced Status Epilepticus
Abstract:The overall objective of this proposal is to demonstrated that imidazenil is a more potent and safer protective agent than diazepam against chemical warfare nerve agent (CWNA)-induced seizure/status epilepticus, neuropathology, and neurobehavioral deficits. Thus we will compare the dose-dependent efficacy of imidazenil or diazepam administered alone and in combination with levetiracetam in protecting rats against diisopropyl fluorophosphate (DFP)-induced toxicity using the following 2 aims. Aim I: To evaluate the dose-dependent efficacies of imidazenil or diazepam administered alone or in combination with levetiracetam in the absence or presence of atropine and/or pralidoxime chloride (2-PAM) against DFP-induced seizure/status epilepticus and neurobehavioral deficits. This will be achieved by telemetric monitoring of cortical electroencephalogram (EEG), core temperature and motor activity. Aim II: To evaluate the effects of imidazenil or diazepam administered alone or in combination with levetiracetam in the absence or presence of atropine and/or 2-PAM on DFP-induced neuropathology. Rat brains will be examined for neuronal degeneration using the deoxyribonucleic acid (DNA) fragmentation measurement and light microscopy histological analysis. These studies may provide new information regarding the potential role of imidazenil in the treatment or prevention of CWNA poisoning and the potential role of the combination of levetiracetam and imidazenil in minimizing CWNA-induced neuropathology.

NOMADICS, INC.
1024 S. Innovation Way
Stillwater, OK 74074
Phone:
PI:
Topic#:
(405) 372-9535
Dr. Shaopeng Wang
CBD 05-117      Awarded: 18MAY05
Title:3D Scaffold and Stem Cell Based Bioengineered Skin for Treatment of Cutaneous Vesicant Injury
Abstract:Vesicants have been used as chemical warfare agents since World War I and are still considered a major class of chemical threat agents both for the military and for homeland security. There are four different vesicating agents: impure sulfur mustard, distilled sulfur mustard, phosgene oxime, and lewisite. Among them, mustard is the most important militarily. The organs most commonly affected by mustard are those come in direct contact: the skin, eyes, and airways. The purpose of this project is to generate large bioengineered skin from embryonic stem cells and skin keratinocytes stem cells with a specially designed 3D hybrid scaffold, for the treatment of vesicant-mediated skin lesions. The scaffold consists of an epidermal supporting layer and an inverted colloidal crystal-based dermal supporting layer. Both layers are constructed with biodegradable material using the layer-by-layer method. Murine embryonic stem cells will be used to generate a skin graft. A mustard stimulant- induced skin injury on the murine will be treated by transplanting the tissue-engineered skin graft for the restoration of epidermal and dermal compartments and the preservation of functional epidermal stem cells for complete healing and long-term restoration of the skin wounds.

CAPE COD RESEARCH, INC.
19 Research Road
East Falmouth, MA 02536
Phone:
PI:
Topic#:
(508) 540-4400
Mr. Francis L. Keohan
CBD 05-118      Awarded: 11MAY05
Title:Toxin-Neutralizing Barrier Skin Cream for CWA Protection
Abstract:The threat of chemical and biological (CB) warfare agent exposure requires a variety of measures to protect military personnel. CB agent entry through the skin can potentially be reduced through the application of chemical barrier creams. Low surface energy fluoropolymers have been shown to resist penetration of both polar and nonpolar chemicals. A new protective skin cream is proposed that utilizes fluorochemical intermediates and known CB neutralizing chemicals to defend against multiple threats. The new protective skin cream is based on a blend of non-irritating film-forming compounds, chemical agent hydrolysis catalysts that concentrate at the film surface and solid particulate neutralization agents that combine to form a highly resistant barrier to the transmission of both hydrophobic and hydrophilic chemicals. The novelty of the approach stems from the dual protection mode offered by a system that self assembles into a multi-layered film for resisting CB agent penetration while quickly neutralizing harmful agents before they reach the skin. The proposed barrier cream will be simple to apply and effectively render the skin highly resistant to the penetration of harmful chemicals and biological agents. The new CB-blocking compounds will be formulated and tested for CB simulant barrier properties, self-decontaminating ability and longevity.

TIAX LLC
15 Acorn Park
Cambridge, MA 02140
Phone:
PI:
Topic#:
(617) 498-5416
Dr. Emily L. Reichert
CBD 05-118      Awarded: 25MAY05
Title:Novel Polymeric Formulations for Skin Protection and Decontamination
Abstract:Currently there is a need for a pre-exposure decontaminating skin cream that will neutralize chemical warfare agents (CWA) on contact. Current approaches to this problem cannot both dissolve a CWA challenge and neutralize the agent into less toxic products before it reaches the skin surface. In response the solicitation CBD05-118 Decontaminating Protective Skin Cream Effective Against Chemical Warfare Agents, a new approach based on a series of proprietary polymers is proposed. The range of possible chemical structures (hydrophilic, amphiphilic, lipophilic or cationic) enables formulations of the polymers to contain a wide variety of actives. In Phase I, we will examine the feasibility of incorporating active moieties into these polymers that neutralize CWAs. The eventual formulation will allow solubilization of both the active moiety and the CWA, enabling a neutralization reaction to occur. The polymers are chemically stable and can be synthesized from available starting materials for a reasonable cost.

APATH, LLC
893 N. Warson Road
St. Louis, MO 63141
Phone:
PI:
Topic#:
(314) 812-8144
Dr. Paul D. Olivo
CBD 05-119      Awarded: 16MAY05
Title:Filovirus drug discovery using novel combinations of approved drugs
Abstract:The goal of this proposal is find novel combinations of approved drugs for the treatment and/or prevention of infection with filoviruses. Ebola and Marburg viruses, the only filoviruses, cause an acute hemorrhagic fever syndrome which has a high mortality rate and poses a significant bio-terrorism threat. There are currently no therapeutic agents available to treat filovirus infections and the development of such drugs is important for bio-defense. Apath has developed a novel, cell-based, infection-independent screening method that is based on replication of an Ebola virus minigenome. This proposal focuses on a strategy of combining existing drugs to discover combinations that have novel anti-filovirus activity. The Apath screening method is very amenable to identifying drug combinations that inhibit EBOV replication. The number of possible combinations of approved drugs, however, is enormous and so a recently described system will be used that identifies combinations of compounds that produce novel activity. This method streamlines the process of defining chemical relationships to enable the discovery of combinations of drugs that exhibit novel synergistic activity. The use of a library of approved drugs, all of which possess biologically activity and bioavailability, should facilitate the development of a therapeutic drug combination because they have desirable pharmaceutical properties.

MICROBIAL AEROSOL RESEARCH LABORATORY, LLC
10975 Doll Road
Monmouth, OR 97361
Phone:
PI:
Topic#:
(503) 838-2264
Dr. Bruce Lighthart
CBD 05-121      Selected for Award
Title:Biological Aerosol Agent Fate Model
Abstract:It is proposed to formulate an equation(s) to describe the (A) evaporation and (B) death rates of aerosolized bacteria in their spent culture fluid droplets. This formulation will account for effects of atmospheric temperature, relative humidity, solar radiation, droplet solute concentration, and droplet size effects perhaps including effects of solute-particle (i.e,, bacteria) concentration and packing. It is proposed to prepare this formulation in broad sense with what is known by the eminent participants in the project: an aeromicrobiologist, an atmospheric physicist, and atmospheric engineer/scientist. Subsequently the following sequence will be followed: (1) search the literature for relevant formulae, (2) prepare computer algorithms expressing the evaporation rate and bacterial survival in their spent culture fluid, and (3) validating the evaporation and death rate model using known data.

ABSOLUTE CLOSURE INNOVATIONS, INC.
104 W. Garfield
Bozeman, MT 59715
Phone:
PI:
Topic#:
(406) 556-1275
Mr. Andrew Seessel
CBD 05-122      Selected for Award
Title:Breathable, Lightweight, Elasticized Carbon-Based Closures for Chemical Warfare Agent Vapor Management
Abstract:Textile technology related to Chemical Biological (CB) protective clothing has made rapid progress from the initial introduction of the Battledress Overgarment to the currently conceived selectively permeable membrane (SPM) ensembles of the Joint Service Lightweight Integrated Suit Technology (JSLIST) and the Joint Protective Aircrew Ensemble (JPACE). Closure system technology has not advanced as dramatically or as successfully. Despite Joint Service demands for a cost-effective CB closure that reduces heat stress, closures are still expensive, bulky, difficult to use, hard to maintain, and an impediment to mission success. The crucial problem of preventing CB agent penetration at the extremity interfaces remains unresolved. Absolute Closure Innovations (ACI) proposes the development of an economical, lightweight, flexible, and elastic CB closure that solves the extremity interface dilemma by forming a seal between the ensemble extremity opening and the peripheral glove, boot, or mask. The closure protects from CB exposure and does not interfere with the warfighter performance. ACI's novel closure can be integrated into current ensembles using standard installation techniques and is appropriate for next generation elasticized SPM concepts. With a recognized and experienced team of designers, engineers, and advisors, ACI is uniquely qualified to develop and commercialize the innovative sealed closure system.

ASPEN AEROGELS, INC.
30 Forbes Road, Building B
Northborough, MA 01532
Phone:
PI:
Topic#:
(508) 481-5058
Dr. Xiangjun Hu
CBD 05-123      Selected for Award
Title:Aerogel-Based Chemical and Biological Protective Fabrics.
Abstract:The Department of Defense has identified the need to develop aerogel-based Chemical/Biological (CB) protective fabrics with good moisture vapor transmission for use in garment and collective protection systems. Aspen Aerogels proposes to develop aerogel-coated fabrics as a novel protection material against chemical and biological warfare agents. The aerogel component will be based on silica and nano-scale metal oxides. Silica serves as a highly porous (> 90 % porosity) support for finely dispersed nano-scale metal oxide powders that can catalytically deactivate the agents. The high surface area and nano-sized pores of the aerogel could be used to sequester the agent molecules in much the same manner as activated carbon. Additionally, metal oxides catalytically deactivate the agents and transform them to non-threatening species. By comparison, water molecules do not interact strongly with the hydrophobic aerogel pore wall or the metal oxides, and therefore will not loose much energy in colliding with the wall and the progress of the molecule will not be significantly slowed or halted. Accordingly, the aerogel-based protective fabrics possess high permeation selectivity between water vapor and agent vapors (high breathability).

UTILITY DEVELOPMENT CORP.
112 Naylon Avenue
Livingston, NJ 07039
Phone:
PI:
Topic#:
(973) 994-4334
Mr. Harry S. Katz
CBD 05-124      Awarded: 13MAY05
Title: Flexible Composite Chemical, Biological, Radiological, and Nuclear (CBRN) Barrier for the Joint Expeditionary Collective Protection System
Abstract:The main objective will be to develop a high-performance flexible composite barrier that provides protection from Chemical, Biological, Radiological, and Nuclear (CBRN) agents and Toxic Industrial Materials (TIMs). UDC will develop a thermoplastic elastomer (TPE) coated fabric to provide CBRN agent resistant tents. Fire retardant capability will be achieved by the addition of fire retardant fillers. Seaming methods such as heat sealing will provide high speed and low cost seaming for tentage, shelters and garments. In the Phase I program, we will identify potential films, polymers and fabric to achieve the required performance characteristics. Physical properties will meet or exceed the requirements of LP/P DES 1-94b including strength and water and vapor resistance of end items. UDC will suggest innovative methods for reducing the cost and speeding the processes associated with creating structural water/vapor proof seams parameters including production rates, hydrostatic resistance, physical properties and costs. Additional tests will be conducted to evaluate permeability of the seamed joints. In addition, one or two materials candidates will be fabricated as thin sheets that will be tested for HD, GD and GB agents. At the end of Phase I, a report with results and conclusions, and a Phase II plan, schedule and cost estimate will be submitted.