---------- OSD ----------

47 Phase I Selections from the 05.2 Solicitation

(In Topic Number Order)
CFD RESEARCH CORP.
215 Wynn Dr., 5th Floor
Huntsville, AL 35805
Phone:
PI:
Topic#:
(256) 726-4800
Dr. Guiren Wang
OSD 05-H01      Awarded: 20DEC05
Title:Novel Miniaturized, Electrothermal Activated, Optically Controlled, Highthroughput Noninvasive Drug Infusion Pump
Abstract:Our objective is to develop a novel, compact, lightweight, and disposable Micropump for safe and precise delivery of pharmacological agents and drugs. The proposed technology will couple recently reported electrokinetic phenomena, electrothermal flow, with an inline flow sensor based on Laser-Induced Fluorescence Photobleaching Anemometry and a feedback controller for automatic, digital control of infusion flow rate. The safety of the system is ensured via precise flow rate control for a specific drug to minimize dosage error. The pump will be designed to provide flow rates in the range of 1-500 ml/hr. The program objectives will be accomplished via several innovations (a) MEMS/microfluidics based architecture, (b) plastic laminates-based fabrication (target cost < $10/piece), and (c) simulation-based design for optimal performance. During Phase I, we will demonstrate two critical components of the system, Micropump and flow sensor. Preliminary Design Review document based on detailed analysis of pumping requirements will be prepared. A design strategy for improved safety features will be developed. In Phase II, integrated system development will be the major focus, with comprehensive design of feedback controller, scale-up and system integration to meet DoD needs. A multidisciplinary team with proven expertise in biomicrosystems engineering, optics and microfabrication has been assembled. The research work will leverage on existing microfluidic product development projects.

PHOENIX ANALYSIS & DESIGN TECHNOLOGIES
7755 S. Research Dr., ASU Research Park, Suite # 1
Tempe, AZ 85284
Phone:
PI:
Topic#:
(480) 813-4884
Dr. Mark C. Johnson
OSD 05-H01      Awarded: 20DEC05
Title:Miniature disposable drug infusion pump with integrated flow meter and bubble detection
Abstract:This project involves the development of a miniature, disposable, infusion system that includes a micropump, novel flow meter, bubble detection, programmability and drug identification, and wireless communications. The phase I effort will result in the development of 3 new technologies: a novel miniature pumping mechanism called a "Annular Valve Micropump", an integrated but independent flow measurement device called a "Balloon flow meter", and a system for detecting gas bubbles. All of these functions are provided from only two major assemblies that are largely made from molded elastomer. The pump valves are annular in design and molded directly into one of the main assemblies. Pump actuation is driven by a 3 Volt coin battery that powers a high-speed (~ 5 Hz) Nitinol actuator. The Balloon flow meter employs an elastomeric section that stretches as it receives fluid - thus pressurizing the receiving cavity. The pressure is measured from a calibrated embedded strain gauge. Bubble detection is provided by the integration of a hydrophilic filter.

PULSE ACTIVATED CELL SYSTEMS
Medipacs, UA Science and Technology Park, 9040 Sou
Tucson, AZ 85747
Phone:
PI:
Topic#:
(520) 382-3264
Ms. Sonia Vohnout
OSD 05-H01      Awarded: 20DEC05
Title:Miniature disposable drug infusion pumps with improved safety features and embedded computer control
Abstract:Medipacs, LLC requests SBIR funding to develop a small, lightweight, and disposable infusion pump that allows safe and programmable delivery of drugs under varying environmental conditions including combat. The infusion pump will be self-contained and designed to operate on military litters. The pump will use electroactive polymer actuators in a Pulse-Activated Cell (PACS) architecture, allowing significant savings in weight and cost while maintaining pump precision. With a target unit price under $20, the Medipacs pump will satisfy an unmet need in the miltary and civilian infusion pump markets.

SARCOS RESEARCH CORP.
360 Wakara Way
Salt Lake City, UT 84108
Phone:
PI:
Topic#:
(801) 581-0155
Dr. Tomasz J. Petelenz
OSD 05-H01      Awarded: 20DEC05
Title:Miniature disposable drug infusion pumps with improved safety features and embedded computer control
Abstract:Sarcos Research Corporation proposes the development of a miniature, disposable, embedded computer-controlled IV infusion pump for administration of drugs during casualty treatment, stabilization and transport on the battlefield. The pump will be based on the Company's proprietary design concepts that enable pumps that are accurate, power efficient, small size, light weight, rugged, and can operate in closed-loop control, or in easy to program manual control mode, in battlefield, casualty transport, and hospital environments. The proposed disposable pump will be easily attachable to the wounded soldier during transport, or on the anesthesia / fluid delivery manifold of automated life support system (such as LSTAT). The pump will be equipped with enhanced safety and monitoring features for flow measurement and control, and with communication, data recording and remote control capabilities. The pump will be economical to manufacture and thus be disposable. Phase 1 will focus on the analysis of design alternatives, development of System Specifications, and feasibility demonstration of principal system components. Phase 2 will address prototyping, product design, testing and regulatory approval, and preproduction engineering development.

THERAFUSE, INC.
2453 Impala Drive
Carlsbad, CA 92010
Phone:
PI:
Topic#:
(760) 579-0880
Mr. Burton Sage
OSD 05-H01      Awarded: 20DEC05
Title:Miniature disposable drug infusion pumps with improved safety features and embedded computer control
Abstract:86% of battlefield deaths occur within two hours of wounding. Large, heavy infusion pumps are unavailable to provide fluid replacement and IV medication when and where it is most needed, costing many of these lives. Medication errors take even more lives. TheraFuse has prototyped a miniature, solid state, optical flow sensor able to make measurements every millisecond at 3% accuracy. This sensor obviates the need for a precision pump and enables closed loop control of any miniature fluid propulsion technology, thereby creating a safe and accurate quarter sized disposable infusion system. Medication error reduction software available from our partner Baxter Healthcare would save additional lives. When coupled with the patient's vital signs, automated pump setup and control becomes feasible, driving the infusion to a pre-programmed therapeutic endpoint. In Phase I, TheraFuse will evaluate fluid propulsion methods to determine which combination of sensor and fluid propulsion technology best fills the military need. In Phase II prototypes will be constructed and tested using animals. TheraFuse's staff has over fifty years combined IV infusion experience. TheraFuse's expertise and technology can create the smallest, safest, most accurate and reliable disposable infusion system for military and civilian use.

LUNA INNOVATIONS, INC.
2851 Commerce Street
Blacksburg, VA 24060
Phone:
PI:
Topic#:
(540) 552-5128
Dr. James Garrett
OSD 05-H02      Awarded: 29DEC05
Title:Optically clear ballistic resistant polymer nanocomposites
Abstract:The modern warfighter is equipped with the best personal protective equipment available today, but that is not enough. Thirteen percent of casualties in Operations Desert Shield and Desert Storm were ophthalmic injuries and only 3% of those injured were wearing protective goggles. There is a real and immediate need for a lightweight, optically clear visor that will provide adequate protection to a soldier. To address this critical need, Luna Innovations proposes a visor made of an optically clear ballistic polymer nanocomposite to provide increased ballistic, abrasion, and chemical resistance, while reducing areal density. The benefits of the polymer nanocomposite are many. The one component system is easier to manufacture than a hard coating over a substrate. There are no delamination or incompatibility (refractive index, coefficient of expansion) issues as would be found in coating/substrate systems. Finally, the polymer nanocomposite is expected to have a uniform abbe number, which is crucial for optical accuracy through a curved face shield. The purpose of the proposed Phase I project is to demonstrate the feasibility of an optically clear ballistic polymer nanocomposite to increase performance while decreasing areal density. This phase will culminate in ballistics testing of sample panels in an effort to demonstrate NIJ Armor Type IIIA rating.

NEI CORP.
Suite 102/103, 201 Circle Drive
Piscataway, NJ 08854
Phone:
PI:
Topic#:
(732) 868-1906
Dr. Amit Singhal
OSD 05-H02      Awarded: 29DEC05
Title:A novel approach to fabrication of polymer-based ballistic resistant materials with low areal density
Abstract:Currently, adequate ballistic protection in optically transparent surface shields and transparent armor is provided either by thick sections of polymers, or by laminated sheets of polymer and glass. In both cases, the areal density is very high. For reasons explained in the proposal, efforts to date on the synthesis of transparent polymer nanocomposite materials, especially those based on polycarbonate, have met with limited success. However, nanocomposites do offer a solution because of the potential for improved mechanical properties (ballistic resistance, scratch and abrasion resistance, and chemical resistance) without compromising the optical clarity. We propose to build upon our current efforts in the area of polymer nanocomposite coatings and bulk materials to develop a novel approach to produce polymer-based ballistic resistant materials that have relatively low areal density. Thinner sections of the proposed material are expected to have the same ballistic performance as much thicker sections of the currently used materials, but exhibit superior abrasion and scratch resistance. The Phase I program will demonstrate the feasibility of synthesizing the materials to achieve the desired results. Relevant mechanical properties will be determined and compared to currently used materials. In addition, the microstructure of the materials will be characterized. A detailed comparison of the ballistic performance of the proposed materials with that of the state-of-the-art will be carried out in Phase II. Additionally, face shield panels will be fabricated and tested.

LUNA INNOVATIONS, INC.
2851 Commerce Street
Blacksburg, VA 24060
Phone:
PI:
Topic#:
(540) 552-5128
Dr. Michael Danilich
OSD 05-H03      Awarded: 18JAN06
Title:Thermosensitive Intracavitary Hemostatic Agent
Abstract:Hemorrhage is the leading cause of death from battlefield trauma. Approximately 80% of hemorrhagic deaths on the battlefield are due to intracavitary hemorrhage that is not accessible to direct pressure. Noncompressible hemorrhage is also a primary cause of death in civilian trauma. Unfortunately, methods available to first responders to control hemorrhage are only useful for extremity or superficial truncal injuries and the only viable treatment for intracavitary hemorrhage is surgical intervention. Luna Innovations proposes to develop an intracavitary hemostatic agent from a thermosensitive sol-gel system that is liquid at room temperature, but gel at 37 C. This novel agent will allow easy delivery of a unique, low-viscosity, neutral pH solution that rapidly increases in viscosity and forms a biocompatible, bioadhesive, biodegradable and hemostatic physical gel within the body cavity. The gelling hemostatic agent will be administered by a delivery system that will provide sufficient tamponade to control capillary/venous bleeding and surface oozing, allow interaction of the agent with injured tissues in the vicinity of pooled and/or flowing blood, and provide an ability to gauge proper positioning and real time assessment of success. The stored and transported liquid hemostatic agent and delivery system will be stable, small, lightweight, low-cost and easy to use.

LIFEWAVE, INC.
311 Lincoln St
Roseville, CA 95678
Phone:
PI:
Topic#:
(916) 781-6500
Mr. J. Paul Tupin, Jr
OSD 05-H04      Awarded: 17JAN06
Title:Use of Non-Invasive Methods to Determine Stroke Volume
Abstract:The current methods for estimating stroke volume rely on respiratory gas analysis, bioimpedance, echocardiography, and catheter-based techniques and are impractical for the battlefield environment. Research into the medical use of Ultra-WideBand (UWB) has shown it is capable of non-invasive collection of a variety of medically significant data and holds promise as a means of estimating cardiac stroke volume. In Phase I, we will demonstrate both in theory and practice that Ultra-WideBand Medical Radar (UWBMR) can detect conditions within the heart that will lead to a determination of changes in stroke volume. We propose to employ a two stage research project to meet the program requirements. First, we will conduct a theoretical analysis of the problem using computer-generated FDTD models of the heart and surrounding thoracic region. The volume of the cardiac chambers will be varied and the effects on the reflected radar energies will be evaluated to determine the UWB device's ability to detect changes in stroke volume. Second, we will validate the results from the computer model with tests on porcine animal models with an UWBMR array and synthetic aperture radar algorithms. Furthermore, we will demonstrate the potential to package the instrument into a hand-held device.

NON-INVASIVE MONITORING SYSTEMS, INC.
1666 Kennedy Causeway, Suite 308
North Bay Village, FL 33141
Phone:
PI:
Topic#:
(305) 861-0075
Dr. Marvin A. Sackner
OSD 05-H04      Awarded: 04JAN06
Title:Use of Non-Invasive Methods to Determine Stroke Volume
Abstract:Quantitative estimation of blood loss in wounded battlefield casualties must be promptly transmitted to medics for corrective actions. Yet heart rate and blood pressure measures are often inadequate, and the more accurate invasive measures of stroke volume as well as derived measures from the ventricular volume curve (obtained with echo-Doppler) cannot be employed logistically. Real-time, battlefield monitoring of such parameters can be achieved with a non-invasive inductive plethysmographic sensor (thoracocardiograph) and ECG. By fitting casualties with these easy-to-apply sensors (one non-constricting elastic band transversely around the chest near the xiphoid process and three ECG chest electrodes), wireless transmission of continuous hemodynamic data can be received on a small, handheld monitoring device with onboard signal processing software for waveform and numerical displays as well as an automatic alarm function when problems are detected. To further support casualty monitoring, these sensors can be easily integrated with others such as blood pressure, etc., all of which could be transmitted wirelessly to the same handheld display and monitoring device along with expert systems data reduction. These features could then be integrated into a more comprehensive, battery-powered physiological monitoring device worn by warfighters to gather and track both pre- and post-injury heath status data.

ADLYFE, INC.
9430 Key West Avenue, Suite 210
Rockville, MD 20850
Phone:
PI:
Topic#:
(301) 424-8344
Dr. Cindy S. Orser
OSD 05-H05      Awarded: 21DEC05
Title:Development of novel methods and reagents for surveillence of prion infection
Abstract:Adlyfe Inc. has developed a highly sensitive fluorescence based test, called the Misfolded Protein Diagnostic (MPD) Assay, for the misfolded prion protein associated with infectivity. The femtomolar sensitivity of the test enables the presymptomatic detection in blood, which can be performed ante mortem in routine surveillance of live animals and in blood screening of the human blood supply. The MPD Assay does not rely on antibodies but mimics the folding activity of prions utilizing a target binding peptide. The amplification of the signal through nucleation of folding of other added binding peptides, allows for the extreme sensitivity of the detection method to be realized. This has been demonstrated in controlled in vitro biophysical studies, controlled models of disease in hamsters and mice, and in endemic disease with blood samples from scrapie sheep, BSE-infected cows and monkey and human sCJD. Current protocols and methodology have been geared toward laboratory bench execution of the MPD assay. Here, we propose to move this exciting new technology forward to a more robust integrated assay system that will ultimately encompass software for data analysis and reporting.

CHRONIX BIOMEDICAL CORP.
1735 N. First Street, Suite 309
San Jose, CA 95112
Phone:
PI:
Topic#:
(408) 441-2071
Dr. Howard Urnovitz
OSD 05-H05      Awarded: 01FEB06
Title:Development of novel methods and reagents for prion infection
Abstract:ucleic acid tests are becoming the diagnostic tools of choice for many rapid screening assays. Circulating Nucleic Acids (CNAs) can be defined as RNA and DNA detected in biological fluids devoid of cellular material. Previous data have clearly showed the diagnostic relevance of the appearance of specific CNAs in a number of chronic diseases. Chronix Biomedical was founded with the objective of developing Circulating Nucleic Acid (CNA) tests for the detection of disease-specific genetic material in serum and plasma from individuals with chronic illnesses. We have found that detected sequences tend to be derived from "repetitive" genomic sequences, and work performed in cattle has clearly indicated the diagnostic potential of this assay for diagnosis of Bovine Spongiform Encephalopathy in cattle (BSE). It is the purpose of this proposal to extend this technology to develop a rapid, CNA-based screening assay for Creutzfeldt Jakob Disease in human peripheral blood. To accomplish this task, we have partnered with the American Red Cross to obtain sufficient blood samples to appropriately define collection, storage, and analysis parameters necessary.

TDA RESEARCH, INC.
12345 W. 52nd Ave.
Wheat Ridge, CO 80033
Phone:
PI:
Topic#:
(303) 940-2338
Dr. Shawn A. Sapp
OSD 05-H05      Awarded: 06JAN06
Title:Molecularly Imprinted, Conducting Polymer-Based Sensors for Infectious Prions
Abstract:Since their identification in the early `80s, pathogenic and infectious proteins called prions have been linked to a number of degenerative neurological diseases in humans and animals. The diagnosis and tracking of these transmissible spongiform encephalopathies (TSEs) is difficult because it can require testing of brain, spinal chord, or lymphatic tissues, often collected post-mortem. Testing requires costly and time consuming antibody-based assays that must be performed by highly trained personnel. TDA Research, Inc. proposes to develop low-cost sensors for infectious prions using molecularly imprinted, conducting polymer materials. This project will focus on the detection of chronic wasting disease (CWD) and will be performed in collaboration with the Wildlife Research Center of the Colorado Division of Wildlife.

BIOTRACES, INC.
13455 Sunrise Valley Drive, Suite 200
Herndon, VA 20171
Phone:
PI:
Topic#:
(703) 793-0907
Dr. Andrzej K. Drukier
OSD 05-H06      Awarded: 06JAN06
Title:The use of proteomics for surrogate markers of prion infection
Abstract:We propose new methods for discovery of TSE biomarkers based on combing the MultiPhoton Detection (MPD) technique with methods of proteomics, especially by applying MPD enhanced differential display of proteins (dd-PROT/MPD). This MPD enabled techniques, developed by the group of Dr. A. K. Drukier, enables more sensitive and less expensive tests for correlating the levels of low abundance protein ("molecular switch") with TSE infections. These differentially displayed proteins will then be validated as TSE biomarkers. The primary objective of Phase I of this proposal is to discover differentially displayed proteins associated with TSE. We will further develop methodology for the Multi Photon Detection (MPD)-enhanced differential display of proteins (dd-PROT/MPD) and apply it to determining proteomic differences in the CSF, brain tissue and blood of healthy and prion infected hamsters. Since the quantitative characterization by 2D-PAGE with the MPD Imager permits the display of proteins with about a 100-fold better sensitivity than current methods (spots with 50 zeptomole of protein can be detected), rare proteins that are expressed differentially in the disease state can be reliably identified. Hopefully, some of them will also be present in blood to allow ante mortem TSE diagnosis.

RURAL TECHNOLOGIES, INC.
1008 32nd Ave
Brookings, SD 57006
Phone:
PI:
Topic#:
(605) 692-6953
Dr. Christopher Mateo
OSD 05-H06      Awarded: 04JAN06
Title:The use of proteomics for surrogate markers of prion infection
Abstract:Prion diseases are unique, in that their exceptionally long incubation period makes it difficult to diagnose prior to end-stage disease. While many diagnostic assays for infectious diseases rely upon detection of specific immunity, prion diseases apparently provoke no detectable immune response. Alternative tests must therefore be developed based upon concomitant changes in gene expression associated with disease progression. While a majority of pathogolical symptoms arise in the CNS, peripheral lymphoid tissues are an alternate site of prion proliferation. These peripehral lymphoid organs would be preferable sites for the analysis of protein expression differences associated with prion disease. The Canadian National Microbiology Laboratories have recently invested in a proteomics facility for the express purpose of analyzing transmissible spongiform encephalopathies. We have partnered with this facility, due to it's unique expertise and proximity to our facility in Brookings, South Dakota. Furthermore, we have arranged to acquire pathological blood and lymph samples from scrapie-infected sheep currently housed at South Dakota State University. Our researchers will then collect and analyze data obtained from these partnerships in order to target specific changes in protein expression associated with prion diseases.

INBIOS INTERNATIONAL
562 Ist Ave S, Suite 600
Seattle, WA 98104
Phone:
PI:
Topic#:
(206) 344-5821
Dr. Syamal Raychaudhuri
OSD 05-H07      Awarded: 30JAN06
Title:Development of a multiplexed point-of-care assay for the detection of infectious agents causing fever in deployed soldiers.
Abstract:This objective of this study is to develop a robust, field-grade, screening assay for the detection of fever-causing pathogens including Plasmodium sp., Salmonella, Rickettsial sp., Flaviviruses and Leptospira. The test will utilize lateral flow (dipstick) chromatography incorporated into a unique, multiplex, cassette that enables the simultaneous screening of multiple analytes. The proposed immunochromatographic assay would be a very useful rapid screening test to assess individuals presenting with fevers of likely infectious etiology. In this Phase 1 study we shall evaluate the ability of a panel of antigens, derived from the families of pathogens listed above, to function as the basis of a serological detection system. We will then construct a prototype assay that will be evaluated against sera from individuals with confirmed infections. Further development of the assay would take place in a Phase 2 proposal.

PANBIO, INC.
9075A Guilford Road
Columbia, MD 21046
Phone:
PI:
Topic#:
(410) 381-8550
Dr. Barbara Hanson
OSD 05-H07      Awarded: 27JAN06
Title:Multiplex point-of-care assay to diagnose infectious diseases
Abstract:A new technology in infectious disease diagnostics will be examined. The test platform will utilize Panbio's patented Oligo Rapid technology, a lateral flow cassette in which analyte binding is mediated through specifi-cally engineered oligonucleotides. The cassette strips themselves will be generic so that they can be readily adapted to a variety of analytes (antibodies and antigens) that are added at the time of the test. In Phase I of this project, a proof-of-principle will be established in the design of a rapid point-of-care diagnostic for detection of serum IgM antibodies to dengue virus. This will lead to further development in Phase II of the capacity to de-tect, in addition, IgG antibodies to dengue virus and circulating dengue virus antigen in serum or in whole blood, all in the same test. Phase I will involve optimization of (i) antigen; (ii) conjugation of antigen to colloidal gold detector; and (iii) conjugation of the capture antibody to the oligonucleotide. In addition, the assembled test will be evaluated as to its robustness, stability, manufacturability, clinical performance, and technical per-formance.

VECTOR TEST SYSTEMS, INC.
2033 Yellowthroat Place
Thousand Oaks, CA 91320
Phone:
PI:
Topic#:
(805) 390-0647
Ms. Priti Dave
OSD 05-H07      Awarded: 02FEB06
Title:Development of a multiplexed point-of-care assay for the detection of infectious agents causing fever in deployed soldiers.
Abstract:VecTOR Test Systems, Inc. will develop the rapid assay for detection of infectious agents causing fever in deployed soldiers in the field. The proposed assays will be performed in a staggered step protocol: First would be to broadly detect the presence of any the main causative group of pathogens by identification of pathogen antigen or immunological/serological response to infection of Malaria, Flavivirus, Salmonella, Leptospira or the Rickettsial pathgens. Based on the results of this assay, a second assay will be performed to confirm and identify the species or type of causative agent from the group identified in the first step assay. The technology is based on the simple and reliable wicking immuno-chromatographic detection method by which sensitive test-strip based assays provide results in less than 30 minutes. The proposed assays will be stable at ambient storage conditions.

FAIRFIELD TECHNOLOGIES, INC.
1200 G Street NW, Suite 800
Washington, DC 20005
Phone:
PI:
Topic#:
(703) 277-7707
Mr. Kenneth Fried
OSD 05-H08      Awarded: 22JAN06
Title:Tool for Pharmacovigilance: for Infectious Disease, Combat Casuality Care and Biological Warfare and Chemical Defense Medications and Vaccines
Abstract:Brief Description of Problem: Pharmacovigilance is a key area required for effective Force Health Protection. While good efforts have been made to address this problem, the traditional systems approaches used do not address underlying challenges such as data quality, unavailability and non-integration, and the expensive person-driven approaches to data mapping and integration inherent in traditional systems integration solutions. Innovations: FTI has successfully demonstrated that grid computing systems can be developed rapidly and fairly inexpensively, given the right toolset, experience, and "best practices". FTI's approach is innovative in that it: applies grid computing to the new application area of pharmacovigilance; employs an innovative open source software business model; and builds upon FTI's standards-based software development "best practices." Project Objectives: FTI's objective is to build a proof-of-concept prototype Advanced Pharmacovigilance Tool (APT) to address DoD's need for a "better, faster, cheaper" pharmacovigilance tool that is more robust, scalable, easier-to-use, more cost-effective, and contains data federation, warehouse, analysis and visualization capabilities. FTI will then refine this product for targeted marketing to government and commercial sectors. Technical Approach: FTI's working prototype will consist of the following components, built on open source/open architecture software: the Data Federation Module, the Data Warehouse Module, and the Data Analysis and Visualization Module. This product will be built on the foundation of the National Cancer Institute's Cancer Bioinformatics Grid (CaBIG) software product, designed to integrate data from multiple clinical trials, augmented by FTI's own grid computing software. FTI will validate prototype performance in a "real world" DoD clinical trials environment.

LOGOBOTS LLC
60 E 32nd Street, #204
Chicago, IL 60616
Phone:
PI:
Topic#:
(312) 328-0252
Mr. Rajeev Priyadarshi
OSD 05-H08      Awarded: 30JAN06
Title:A Standards-Based Tool for Pharmacovigilance
Abstract:Clinical trial data is insufficient for drug safety purposes since not enough patients are covered. Hence the drug design process can be improved if post-marketed safety data can be used to augment data available from clinical trials. The FDA and WHO are some agencies that make such safety data available for pharmacovigilance purposes. The DOD aims to create a data warehouse that combines such public-domain post-marketed drug/vaccine safety data with pre-marketing clinical trial data. Data mining and other analytical tools will also be needed to discern patterns that can be used to aid drug safety procedures in the drug development process. The proposed work will adopt a standards-based approach to this task. There are a variety of relevant healthcare standards that need to be considered while crafting a solution. Such an approach will ensure that the developed software can interoperate with existing and emerging DOD medical research information systems.

ONTAR CORP.
9 Village Way
North Andover, MA 01845
Phone:
PI:
Topic#:
(978) 689-9622
Dr. John Schroeder
OSD 05-H08      Awarded: 13JAN06
Title:Tool for Pharmacovigilance: for Infectious Disease, Combat Casuality Care and Biological Warfare and Chemical Defense Medications and Vaccines
Abstract:Ontar proposes to design and implement a pharmacovigilance system and analytic database to rapidly and accurately evaluate the safety of marketed and to-be-developed drugs, vaccines or other treatment agents from disparate pre- and post-marketing clinical data trials and other sources. This will include development of a data mining tool to detect both known and unknown safety signals in the FDA, WHO, CHCS, clinical trials and other databases; provide careful, innovative data preparation (code mapping, redundancy removal); develop advanced screening algorithms; implementation of user-friendly interfaces (including a web-based portal) and cognitive report displays. The system can form part of an active surveillance system to provide rapid and accurate safety signal evaluation, or can be used as a medical investigative product for both military and civilian (i.e. pharmaceutical and health industry) purposes.

PROSANOS CORP.
225 Market St, Suite 502
Harrisburg, PA 17101
Phone:
PI:
Topic#:
(717) 635-2124
Mr. Alan Hochberg
OSD 05-H08      Awarded: 08DEC05
Title:Flexible Pharmacovigilance System for Data Visualization and Signal Detection
Abstract:The objective of this Phase I proposal is to lay the groundwork for the integration of specific novel drug-safety concepts into a tool for data analysis and visualization at DOD. The novel concepts include: 1) A flexible, probability-based model which assesses the signal strength of both rare and common adverse events without complex "shrinkage" algorithms; 2) A "pharmacovigilance map", which allows visual assessment of drug safety profiles; 3) A lattice-based visualization technique particularly suited to drug interactions (drug-drug, drug-vaccine, drug-demographic, drug-disease) which can help distinguish true drug interactions from "innocent bystander" effects; 4) An underlying data model for all three of the concepts above, which can accommodate drug safety data from clinical trials, spontaneous reporting systems, and patient-oriented databases such as electronic medical record systems.

ENERGID TECHNOLOGIES
124 Mount Auburn Street, Suite 200 North
Cambridge, MA 02138
Phone:
PI:
Topic#:
(888) 547-4100
Dr. John Hu
OSD 05-H09      Awarded: 05JAN06
Title:Regional Anesthesia Simulator for Training of Resident and Staff Pain Management Specialists
Abstract:Engaged American troops suffering injuries to the extremities are best treated with regional anesthesia, which renders only a portion of the body, such as a limb, insensate. However, it is possible for long-lasting damage to occur when regional anesthesia is improperly applied, and a training system is needed that teaches anesthesiologist all aspects of regional anesthesia application. The system must be accurate, intuitive, and convenient. Energid Technologies is proposing just such a training system. It includes instructional content in a standard, configurable framework and immersive simulation of procedures to reinforce the instructional content. An anesthesiologist will practice in a virtual environment--with visual, tactile, and auditory feedback--and validation of the content will be supported by surgeons at Massachusetts General Hospital. Since the trainer needs to be accessible to all applicable medical personnel (wherever they might be stationed), it will be small and compact. To create the proposed system, Energid will leverage existing medical simulation technology being developed for the Army and will develop a novel portable MR-based (magneto-rheological) haptic device appropriate for regional anesthesia simulation. The device will provide high fidelity force feedback for needle insertion and injection, and will be particularly beneficial to battlefield regional anesthesia training.

TOUCH OF LIFE TECHNOLOGIES
12635 East Montview Boulevard, Suite 100
Aurora, CO 80010
Phone:
PI:
Topic#:
(303) 724-0514
Dr. Karl D. Reinig
OSD 05-H09      Awarded: 22DEC05
Title:Regional Anesthesia Simulator for Training of Resident and Staff Pain Management Specialists
Abstract:ToLTech will design a realistic and adaptive, virtual reality based simulator for practicing regional anesthesia skills on any part of the human body. The simulator will use haptic and graphic display to give the student the experience of feeling and seeing the interaction of each tool, including needles, with the virtual patient. The simulated patients will be derived from the Visible Human and will respond to both nerve stimulation and drug induced blockage in response to the position of the needle tip when either stimulation is applied or anesthesia injected. The simulator will be combined with a Mentor program that will guide and test the development of the student. This training tool can be used and reused in a learner-centered environment and utilized at the user's pace and time. A full curriculum for nearly all regional anesthesia procedures will be provided in the Phase II portion of this grant. Milestone demonstrations of the fidelity of the virtual anatomy and needle will be available during the Phase I portion of the grant. In addition, one full regional anesthesia lesson will be demonstrated by the Mentor program during the phase I.

VEREFI TECHNOLOGIES, INC.
246 S. Market Street
Elizabethtown, PA 17022
Phone:
PI:
Topic#:
(717) 367-2724
Dr. Randy S. Haluck
OSD 05-H09      Awarded: 10JAN06
Title:Regional Anesthesia Simulator for Training of Resident and Staff Pain Management Specialists
Abstract:Survivable trauma to the extremities has become an increasingly common occurrence in the battlefield with the use of improved body armor and improvised explosive devices by the enemy. These injuries require both prompt and longterm treatment. Regional anesthesia offers several advantages in these circumstances: immediate analgesia and postoperative pain control, prolonged sympathetic blockade that may increase regional blood flow to the injured tissue, and pre-emptive analgesia that minimizes the occurrence of phantom limb syndrome if the injured extremity subsequently require amputation. However, many anesthesiologists and nurse anesthetists have only limited experience in regional anesthesia. At present the only methods for training in regional anesthesia or regional blocks for pain management are using a living human patient or lightly embalmed cadavers in a fresh tissue laboratory as no realistic workable simulators are available. We propose to develop a small footprint, hybrid simulator with active and passive hapticsusing advanced materials and novel,low-cost sensors. Our approach will permit low cost training in a variety of regional anesthetic techniques with nerve stimulation and ultrasound guidance to ensure maximum success. Our Phase I proposal has three objectives: 1. To develop a design document for a prototype regional anesthesia trainer; 2. Develop prototypes where appropriate to demonstrate technical feasibility; 3. Establish performance metrics and determine a method to validate the effectiveness of the simulator in training combat medics, EMTs, anesthesiologists, nurse anesthetists, and physicians in pain medicine.

YANTRIC, INC.
31 Cross Street
West Newton, MA 02465
Phone:
PI:
Topic#:
(617) 332-0539
Dr. Mandayam A. Srinivasan
OSD 05-H09      Awarded: 20JAN06
Title:Regional Anesthesia Simulator for Training of Anesthesia Care Providers
Abstract:The sophistication of weapons and the advances in protective armor in recent years has resulted in a change in typical injuries in combat situations. More and more soldiers sustain and survive catastrophic injuries to their extremities. Regional anesthesia is highly valuable in this context, providing effective pain management during medical evacuation, surgery and post-operative care. However, regional anesthesia is not a consistent part of typical medical training programs today. The goal of this effort is to develop a virtual training system to provide widespread and mass-deployable training to military anesthesiologists. The training system will initially target the infraclavicular brachial plexus block, which is a highly effective block to manage pain in traumatic injury to an upper extremity in combat. This block also has widespread civilian appeal due to its effectiveness in supporting orthopedic surgery to the hand, wrist, elbow and distal arm. Our training system will be easily adaptable to simulate other nerve blocks as well. We believe this training system will substantially improve the quality and accessibility of training to field personnel and has widespread applicability in the commercial space.

DIGILORE, INC.
100 Techne Center Drive, Suite #125
Milford, OH 45150
Phone:
PI:
Topic#:
(808) 989-0364
Dr. Thomas E. Burton
OSD 05-H10      Awarded: 19JAN06
Title:Mechanisms for Hands-Free Point of Care Data Entry in Combat Environments
Abstract:Caregivers have a responsibility, in high stress of combat environments, to collect/report data that documents injury event, severity, care, and outcome. Gathering such data accurately and completely is critical to patient care. Accurate data is also needed to support operation/logistics planning, force modeling, casualty forecasting, training, and compliancy. The military and its research partners have already developed effective mobile tools such as Battlefield Medical Information System - Tactical (BMIST) for collecting data at the point of care, but so far the data input interfaces are incapable of reliably capturing critical patient encounter data in the harsh battlefield environments. This research will explore innovative cutting-edge technologies that will enable military care providers to access and enter patient encounter data in combat environments into a BMIST device using a hands- and eyes-free interface. The research will demonstrate how comprehension and context of verbal utterances in BMIST improves human-machine interactions. The utilized technologies will be robust enough to withstand the noise, vibration, and generally harsh environment of the battlefield. Other focus areas include an analysis of innovative technology alternatives for data collection and input at the point of care, creation of a preliminary architecture comprising the most promising approaches and assessment of its feasibility.

HANDHELD SPEECH LLC
18 Hillside Ave
Amesbury, MA 01913
Phone:
PI:
Topic#:
(978) 388-0396
Dr. Gregory Gadbois
OSD 05-H10      Awarded: 10JAN06
Title:Mechanisms for Hands-Free Point of Care Data Entry in Combat Environments
Abstract:We propose to test a new approach to cope with background noise environments during speech recognition. In the process we will give the BMIST group a data point of how well their recognition problem is handled by our speech recognizer.

LI CREATIVE TECHNOLOGIES
30 A Vreeland Road, Suite 130
Florham Park, NJ 07932
Phone:
PI:
Topic#:
(973) 822-0048
Dr. Qi (Peter) Li
OSD 05-H10      Awarded: 10JAN06
Title:Mechanisms for Hands-Free Point of Care Data Entry in Combat Environments
Abstract:A novel and promising solution for hands - and eyes-free voice interface for point-of-care data entry is proposed. The solution consists of the following major modules: a recently-developed noise-reduction microphone, a Bluetooth earphone, an automatic speech recognizer, a text-to-speech synthesizer, and a dialogue manager. To make the developed system useful in combat environments, we emphasize on noise robustness and user-friendly dialogue management. Our unique new research results and algorithms in noise and recognition robustness are applied; new development language and tools for dialogue management are used in the system integration. Every effort has been made to minimize the project risk and deliver a useful system in this project.

INFOSCITEX CORP.
303 Bear Hill Road
Waltham, MA 02451
Phone:
PI:
Topic#:
(781) 890-1338
Mr. Jeremiah Slade
OSD 05-H11      Awarded: 31JAN06
Title:Biomechanical & Physiological Monitoring of Amputees Using Neural Network Processing
Abstract:In this program Infoscitex will develop a wearable electrotextile system that collects data from a suite of physiological and biomechanical sensors, pre-processes the signal and wirelessly transmits the data for further analysis and interpretation by a Neural Network (NN). This system will incorporate accelerometers, strategically located electromyography (EMG) sensors, and pressure pads in the soles of the feet. The use of a neural network to process the sensor data will allow information to be extracted that is not available to conventional regressive models. This will include information on biomechanical efficiency, gait disturbances, and energy expenditure (EE) due to static and dynamic exertion. While systems are currently available that provide some of this information none provide the complete picture, particularly when it comes to monitoring complex tasks. These systems are instead limited to monitoring simple lower body activities such as walking, running, or cycling. The proposed system will allow for the monitoring of these activities as well as more complex tasks such as those involving both the upper and lower body, static loads, and various sources of gait disturbance such as prosthetic devices. These revolutionary capabilities will allow medical personnel to monitor soldier amputees in the field during the performance of activities such as those covered in the Soldier's Manual of Common Tasks (SMCT) that are critical to their remaining on active duty.

TENXSYS, INC.
408 S. Eagle Road, Suite 201
Eagle, ID 83616
Phone:
PI:
Topic#:
(208) 938-8110
Ms. Layne Simmons
OSD 05-H11      Awarded: 31JAN06
Title:Advanced Biomechanical and Physiological Monitoring System for Amputees and Rehabilitating Personnel
Abstract:This SBIR Phase I project will develop a health and motion monitoring sensor and analysis system to support the return of military personnel with prosthetic devices to active duty. DoD is allowing increasing numbers of Soldiers with prosthetics to return to active duty if they are performance capable, minimizing the loss of their valuable core expertise to the services. There are significant challenges to monitoring physiological/biomechanical parameters of rehabilitating personnel in a non-laboratory environment and providing useful performance capability assessment data. This project will demonstrate that a small, non-intrusive sensor system can be developed using modifications and integration of existing TenXsys technologies that can provide real time and long-term data recording of human movement patterns and energy expenditure through motion and physiological monitoring. TenXsys, in conjunction with the Center for Orthopedic and Biomechanics Research will produce a field-capable Sensor Monitoring and Relay Transmission (SMART) system that will improve amputee monitoring, decreasing the likelihood of injuries due to overexertion and balance instability events. This effort will demonstrate the SMART system capabilities and its advanced capability potential for wireless operations and near-real time monitoring and analysis of physiological/biomechanical parameters by external monitors, such as PCs and cell phones.

ACTIVE SIGNAL TECHNOLOGIES, INC.
611Q N. Hammonds Ferry Rd.
Linthicum, MD 21090
Phone:
PI:
Topic#:
(410) 527-2031
Mr. John Sewell
OSD 05-H12      Awarded: 04JAN06
Title:Portable Pulmonary Injury Diagnostic Device
Abstract:Pneumothorax is a serious and potentially fatal warfighter injury that is difficult to diagnose in the high noise environment of the battlefield. Diagnostic methods beyond percussion, ineffective in the presence of high ambient noise, include large systems unsuitable for the first responders, such as CT scan equipment. Therefore a system that is small, portable and accurate that can operate in these environments is required. Active Signal Technologies proposes to develop such a system based on its experience with non invasive brain pathology diagnostics and its successful development of a noise immune electronic stethoscope that has been tested in the presence of ~ 110 dBA UH60 noise. In Phase I we will model, design and build such a system and perform preliminary clinical tests in the R Adams Shock Cowley Shock Trauma Center to demonstrate its capability to assess the presence and extent of pneumothorax. The device will be PDA based, and be noise immune with a display that will be useful in high noise environments.

STETHOGRAPHICS, INC.
21 Wayside Road
Westborough, MA 01581
Phone:
PI:
Topic#:
(617) 983-4436
Dr. Raymond Murphy
OSD 05-H12      Awarded: 04JAN06
Title:Portable Pulmonary Injury Diagnostic Device
Abstract:About 15% of combat injuries sustained during conventional land warfare involve thorax wounds. Many intrathoracic wounds cause pneumothorax (PTX). PTX is clinically defined as a collection of gas or air in the pleural space, the space that surrounds the lung. This loss of pleural integrity causes the lung to collapse, significantly impacting respiration. A relatively simple procedure of chest tube placement can correct PTX. First responders are trained to perform a chest tube placement procedure. However, PTX is difficult to diagnose on the battlefield. A non-invasive diagnostic tool available to first responders for detecting pneumothorax in the presence of high ambient noise would improve casualty treatment on the battlefield and during transport. This proposal will result in development of a handheld device for diagnosis of PTX based on percussion and auscultation. The device will be low cost and provide automated diagnostic information with an easy to understand display. Our data indicate that this device is feasible and that the development of a commercialized handheld PTX detector is possible within 1 to 2 years. Our company has considerable experience in clinical studies of lung sounds, including Pneumothorax. We also have established capabilities for developing medical devices and securing FDA approval.

TESSONICS, INC.
251 Merrill St., Suite 200, attn: Dr. Maev
Birmingham, MI 48009
Phone:
PI:
Topic#:
(248) 576-1849
Dr. Roman Maev
OSD 05-H12      Awarded: 04JAN06
Title:Portable Pulmonary Injury Diagnostic Device
Abstract:The technical objective of this proposal is to develop and test a novel technological concept that utilizes the principles of medical percussion and, further, to design, assemble and test a bench-top model of this diagnostic device. A theoretical model of a contact source for low frequency sound radiation will be developed and the acoustic frequency spectra of both the radiated and received signals will be numerically computed. The model will consider in detail the effective coupling that exists between the external oscillations generated by the low frequency sound source and the motion of the biological tissue at the point of contact. The acoustic impedance for different ratios of gas and liquid in the biological tissue will be calculated. Optimal frequency ranges, receiver sensitivities other such system parameters will be established. Several versions of actuators will be designed and tested. Different types of the signals (i.e. pulse, linear, frequency modulated, controlled noise) will be tested and compared. A few different receivers, such as pressure transducers, accelerometers and sensors, will be evaluated with respect to impedance measurements. An operating bench-top model of a diagnostic device will be built. A percussion sensor will be developed, calibrated and tested on lung-like tissues. As a PC will be used for data collection and processing, a multi-channel interface between the percussion device and the PC will be designed.

ANCO ENGINEERS, INC.
1965 A 33rd Street
Boulder, CO 80301
Phone:
PI:
Topic#:
(303) 443-7580
Dr. Paul Ibanez
OSD 05-H13      Awarded: 04MAY06
Title:Vertical Linear Accelerator for Dynamic Visual-Vestibular Acuity Health Status Evaluation and Desensitization Training
Abstract:Military platforms expose personnel to extreme vertical vibrations. These vibrations can induce visual-vestibular disturbance or even permanent injury, resulting in spatial-disorientation-related mishaps or decreased performance due to motion-sickness. ANCO Engineers, Inc. proposes to investigate the feasibility of a human-rated, computer-controlled, innovative Vertical Linear Accelerator (VLA) with chair-mounted Visual Acuity Projection System (VAPS), to be used to assess visual acuity during vibration which simulates field conditions. A VAPS will be prototyped, hardened, and tested with an existing motion device. The effectiveness of the acuity-testing protocol in providing a more systematic and sensitive health status evaluation will be determined. There is evidence that repeated exposures to vertical linear motion, such as that which will be produced by the VLA being delineated in Phase I, can be used as a desensitization tool for a chronically motion-sick aircrew. A preliminary protocol for rehabilitation by desensitization will be evaluated. ANCO has provided vibration devices to the military and private industry for 34 years. The potential private-sector market for the VLA/VAPS is large; in the government sector, any DoD component deploying platforms which induce the visual-vestibular effect has a potential interest in this device.

CREARE, INC.
P.O. Box 71
Hanover, NH 03755
Phone:
PI:
Topic#:
(603) 643-3800
Dr. Anthony J. Dietz
OSD 05-H13      Awarded: 14APR06
Title:Visual Vestibular Test Device for Screening and Desensitization Training
Abstract:The maneuvers and vibrations of modern military vehicles result in accelerations that can affect the ability of operators and occupants to read platform-fixed displays. Reflexive interactions between the visual and vestibular systems and pathology that affects these reflexes can affect dynamic visual acuity, impairing the performance of vehicle and system operators, and risking mission success. The motion stimuli can also induce motion sickness in susceptible individuals, resulting in further performance impairment. There are no field devices for evaluating dynamic visual acuity during non-voluntary translational motion. We propose to develop a computer controlled Visual Vestibular Test Device (VVTD) that will enable dynamic visual acuity testing and motion sickness desensitization training to be routinely administered by technicians with minimal training. The feasibility of the proposed device will be demonstrated in Phase I, and the device will be fabricated, validated, and installed at a military base in Phase II. The results of a detailed test program using this device will then be used to develop a low-cost lightweight device that can be used in the field.

DYNAMIC STRUCTURES & MATERIALS, LLC
205 Williamson Square
Franklin, TN 37064
Phone:
PI:
Topic#:
(615) 595-6665
Dr. JEFFREY S.N. PAINE
OSD 05-H13      Awarded: 18APR06
Title:Vertical Accelerator for Visual-Vestibular Acuity Testing and Training
Abstract:Military personnel are often subjected to significant amounts of vertical acceleration while carrying out their duties. This acceleration can interfere with the person's ability to perform their required tasks due to the vestibular ocular reflexes caused by viewing a platform fixed display. Also, it has been shown in literature that repeated exposure to this type of motion can desensitize a person from these natural reflexes. The development of a vertical lift mechanism and training station that can provide an important test/measurement/training function is proposed to provide the basis of a tool for testing and desensitizing of military individuals. Proposed for the test station is a vertical linear stage directly driven via high force linear motor technology. The carriage of this stage will include a chair and restraint system as well as a projection device for displaying visual optotypes. The system will include a fail safe brake system and all necessary redundancies to ensure the safety of the human subject.

NEURO KINETICS, INC.
128 Gamma Drive
Pittsburgh, PA 15238
Phone:
PI:
Topic#:
(412) 963-6649
Dr. Alexander Kiderman
OSD 05-H13      Awarded: 01MAY06
Title:Vertical Linear Accelerator for Dynamic Visual-Vestibular Acuity Health Status Evaluation and Desensitization Training
Abstract:Military environments with high complexity and high levels of motion can cause motion sickness, decreasing operational performance. By integrating a motion simulator and visual acuity testing system, a screening and desensitization system can be realized. The proposed effort wil demonstrate the feasibility of such a system and provide direction for future development efforts.

SPACE HARDWARE OPTIMIZATION TECHNOLOGY, INC.
7200 Highway 150
Greenville, IN 47124
Phone:
PI:
Topic#:
(812) 923-9591
Mr. Tony Shulthise
OSD 05-H13      Awarded: 09APR06
Title:Vertical Linear Accelerator for Dynamic Visual-Vestibular Acuity Health Status Evaluation and Desensitization Training
Abstract:Mitigating Spatial Disorientation (SD) events is of particular interest to the military due to the severe repercussions of such events during flight or in general task performance for certain non-flight activities. Researchers have determined that these events could be mitigated by screening aircrew and other critical staff for visual acuity problems using a vertical oscillating motion system. The SHOT Vertical Linear Accelerator (VLA) system utilizes cutting-edge technologies to provide a safe, human-rated motion system operated via a user-friendly interface and running any desired motion profile within the defined design constraints. SHOT's VLA system is packed with the latest technologies. SHOT's proposed solution utilizes linear motor and servo controller technologies to provide a scalable vertical oscillation capability that can achieve 12 feet or more of displacement with peak accelerations up to 1-g. SHOT's solution incorporates the latest in multi-zone safety alarm and restraint systems to ensure personnel safety. A high-resolution programmable optotype display is included for visual acuity testing and for use with motion sickness desensitization protocols. SHOT mastered these technologies as part of previous experience developing vestibular test equipment for university research. The SHOT VLA system is the next generation of advanced hardware for visual acuity and vestibular testing.

ARCHINOETICS, LLC
733 Bishop St., Suite 1820
Honolulu, HI 96813
Phone:
PI:
Topic#:
(808) 221-2131
Dr. J. Hunter Downs III
OSD 05-H14      Awarded: 29DEC05
Title:MedNet: Consortium
Abstract:An increasingly common military medical need is the need for in-the-field acquisition of symptomatology, differential diagnosis of diseases potentially previously unseen by the medical professional, and identification of symptoms to the population at large. This need suggests a combination of intelligent diagnostic decision aids and knowledge gathering agents overlaid onto a highly flexible physiologic sensor and advanced connectivity infrastructure accessible by cognitively overloaded or untrained users. This Phase I proposal describes work to research, design, and simulate a conceptual approach to creating the MedNet: a deployable network of medical intelligence gathering and diagnostic assistance in the field. The following specific technical objectives will be pursued in Phase I: (a) define technical requirements for MedNet (b) research and design framework and interfaces for creating MedNet; (c) construct MedNet Architecture Specification; (d) leverage existing work to demonstrate feasibility of approach; and (e) report on Phase I activities, results, conclusions, and recommendations for Phase II in final report.

CHI SYSTEMS, INC.
1035 Virginia Drive, Suite 300
Fort Washington, PA 19034
Phone:
PI:
Topic#:
(215) 542-1400
Dr. Russell Maulitz
OSD 05-H14      Awarded: 28DEC05
Title:A Cognitive Agent Approach to MedNet Development
Abstract:CHI Systems, Inc., proposes to develop a smart system to aid field medics and other front-line medical personal in diagnosing and treating combat (and non-combat) injuries. Called MedNet, this system also provides a database of specific cases that can supplement the information provided by MedNet's internal diagnostic and treatment-aiding algorithms, as well as tools for the medic to create new case-entries in the database and to share them in the local and global battlespace. Because prior research has shown that breadth-first exhaustive search diagnostic algorithms are difficult and time-consuming to use, the diagnostic algorithms in MedNet are more heuristic in nature, using a combination of tagged semantic networks and cognitive agent technology to capture and mimic the diagnostic and treatment reasoning processes of experts and make these available to the field medic. The heart of MedNet is cognitive agent software that manages, reasons about, and maintains a model of the patient's recovery process, and that communicates context-sensitive diagnostic and treatment information directly to the field medic. Phase I will produce both a complete MedNet design and a proof-of-concept prototype focusing on a specific scenario involving neck injury, which is an increasingly common problem in Operation Iraqi freedom.

INTELLIGENT AUTOMATION, INC.
15400 Calhoun Drive, Suite 400
Rockville, MD 20855
Phone:
PI:
Topic#:
(301) 294-5223
Dr. Margaret Lyell
OSD 05-H14      Awarded: 12JAN06
Title:A Small, Smart Medical System for the Soldier: the MedAgent System for Medical Diagnosis, Informatics and Treatment Support
Abstract:We approach the development of MedNet from the perspective of modern intelligent systems design. In this project, the elements of modern small smart systems are designed to act in synergy to support a soldier's medical needs. In the design, small sensor devices on the soldier capture health status. Medical software support is hosted in a distributed manner, over a wireless connection, between the sensor devices and the PDA (which captures health status), and to a `ruggedized' laptop hosting medical databases and Grid Agents. Even though the MedNet system is `small', it provides multi-modal interfaces to medical personnel. Logical connectivity for the main elements of the system's software components is provided by software agent technology. Software agent system design is robust in the face of asynchronous communications, multiple activities, and de-centralized systems, and is well suited to interface with resources or external systems, such as TMIP. Software agent technology supports intelligence in the MedNet System; through the algorithmic structure of Grid Agents; in the agent-mediated knowledge store that is the medical cases database and its updates, in medical case retrieval and diagnosis support, in ontological support, and in how the agent-based user interface is designed and user requests agent- supported.

LOGOBOTS LLC
60 E 32nd Street, #204
Chicago, IL 60616
Phone:
PI:
Topic#:
(312) 328-0252
Mr. Rajeev Priyadarshi
OSD 05-H14      Awarded: 29DEC05
Title:Multi-Agent Multi-Modal Framework for MedNet
Abstract:Combat medics are under stress due to various factors including time pressure. They are likely to err in making decisions when confronted with less familiar injuries. MedNet addresses this problems using three components: a multi-modal database to record present encounter as well as historical case studies, a tag to capture real-time measurements, and a multi-agent grid to provide decision support. With the recent rapid advances in mobile computing technologies, it is now feasible to quickly prototype an open system that can integrate with existing systems such as TMIP.

QUANTUM LEAP INNOVATIONS, INC.
3 Innovation Way, Suite 100
Newark, DE 19711
Phone:
PI:
Topic#:
(302) 894-8020
Dr. Donald Steiner
OSD 05-H14      Awarded: 29DEC05
Title:MedNet/AMAs - Adaptive Medical Agents for Medical Diagnosis and Treatment
Abstract:Adaptive Medical Agents (AMAs, pronounced "amaze") provide robust, timely, decision support for emergency care providers in the field. These agents constantly monitor the physiological status of an at-risk population, anticipate requests for analyses and offer both probabilistic assessments and potential courses of treatment. Using a distributed, decentralized architecture, AMAs will exploit broadband communications where and when they are available, but will be capable of working autonomously, when conditions limit connections to outside resources. Development of the system architecture to support the AMA and to allow the maximum degree of flexibility, habitability, graceful degradation, and performance is the main challenge of Phase I of this proposal.

ACTIVE SIGNAL TECHNOLOGIES, INC.
611 N. Hammonds Ferry Rd
Linthicum, MD 21090
Phone:
PI:
Topic#:
(410) 527-2031
Mr. John Sewell
OSD 05-H15      Awarded: 14NOV05
Title:Smart Hemodynamic Monitoring System for Critical Care Air Transport Team (CCATT)
Abstract:Aeromedical evacuation (AE) involves prolonged transport of injured warfighters at risk for clinical deterioration under austere medical conditions. Because of their injuries they have a high potential for progression of recognized and/or occult additional injuries leading to acute instability during Critical Care Air Transport Team (CCATT) transfer. While the CCATTs have a great depth of medical experience in aeromedical evacuation of critically injured warfighters, their care can benefit from additional direct hemodynamic and neurologic information to complement that obtained through normal medical monitoring, specifically Propaqs. Active Signal Technologies proposes to employ passive acoustics to track patient condition in this severe environment and provide alerts to the CCATT when a condition changes and the patient requires additional and immediate medical attention. Specifically, the system will build upon a hand held PDA based system now under test at the R Adams Cowley Shock Trauma Center to monitor both resuscitation status and brain perfusion. It will have the capability of hemodynamic stability and neurologic status monitoring and will use a data base of perfusion status signal analysis accumulated over a period of 8 years to help interpret the data gathered by the CCATT.

DEFENSE RESEARCH TECHNOLOGIES, INC.
3150 Adderley Court
Silver Spring, MD 20906
Phone:
PI:
Topic#:
(301) 871-2636
Dr. Tadeusz M. Drzewiecki
OSD 05-H15      Awarded: 11NOV05
Title:Smart Hemodynamic Monitoring System for Critical Care Air Transport Team (CCATT)
Abstract:Defense Research Technologies, Inc. proposes to analyze, design, simulate, and evaluate the feasibility of a smart hemodynamic monitoring system for the Critical Care Air Transport Teams (CCATTs). Of particular interest is our ability 1) to non-invasively measure bulk density, viscosity, specific heat, and concentrations of CO2, O2, 2) to use these non-invasive measurements in calculating short and long term fluctuations in cardiac output and hemodynamic values over multiple hours in flight, and 3) to use decision tree analysis to provide continuous smart informed alerts and recommendations about hemodynamic stability (pre-and post-interventions). Our proposed integrated system consists of: 1) a microfluidic gas sensor-analyzer with breath-by-breath outputs of bulk gas properties from which individual species concentrations are calculated; 2) compensated spirometer flow measurements for density and viscosity; 3) calculation of pulmonary functions - respiratory quotient and metabolic; 3) hemodynamic sensors for cardiac and blood measurements; 4) single breath calculational process for cardiac output, mixed-venous and end-capillary CO2, O2 pressures, physiologic deadspace, alveolar ventilation rate, CO2 production, and O2 consumption; and 5) an intelligent decision tree analysis for recommending treatment options. We will design, model, and simulate a prototype of a low cost, continuous, safe, non-invasive hemodynamic monitor, which makes simultaneous measurements at 30Hz.

PROGENY SYSTEMS CORP.
9500 Innovation Drive
Manassas, VA 20110
Phone:
PI:
Topic#:
(703) 368-6107
Mr. John Sevick
OSD 05-H15      Awarded: 01DEC05
Title:Smart Hemodynamic Monitoring System for Critical Care Air Transport Team (CCATT)
Abstract:Development of a COTS-based, open architecture, ruggedized monitor for use as an "intelligent assistant" for the treating physician in aeromedical evacuation to assist with a critically ill but stabilized patient. The system utilizes direct feeds of hemodynamic data and manual entries of appropriate parameters, processes the information to determine hemodynamic stability and autonomic state, and give treatment suggestions to the team leader. The system design mitigates the adverse influences of the environment in military transport aircraft including ergonomically improved graphical interface, visual and audio alarms, and data interfaces.