---------- OSD ----------

39 Phase I Selections from the 08.2 Solicitation

(In Topic Number Order)
Empirical Technologies Corporation
P.O. Box 8175
Charlottesville, VA 22906
Phone:
PI:
Topic#:
(434) 296-7000
David W. Gerdt
OSD 08-H01      Awarded: 3/31/2009
Title:New Methods to Monitor Health Status and Clinical Laboratory Data
Abstract:Empirical proposes to further develop and clinically validate a complete solution for a rugged, multi-parameter, vital signs monitor. The device, CareTaker, fits inside the palm like a small hockey puck and attaches to a small finger cuff. Once calibrated with a conventional sphygmomanometer, CareTaker will continuously monitor beat by beat blood pressure, heart rate, respiration rate, and hemorrhaging for 100 hours on a battery charge. Two temperature sensors and a provision for an oximeter will be added to the hardware. The software will be embedded into a new processor within the device. Communicating with CareTaker is via Bluetooth to PDAs, PCs, or smart phones. Charts representing trends in physiological parameters may be uploaded. Notes may be added to the virtual chart that will follow the patient to hospitals and home. An LCD is available for radio free use. One proposed clinical investigation will use CareTaker on patients in a MICU who have an arterial catheter. This will verify the ability of CareTaker to accurately track changing blood pressure. Another clinical investigation will use blood donors who effectively hemorrhage a pint of blood. This will verify that CareTaker can effectively monitor bleeding, whether internal, external, or under a bandage.

Linea Research Corporation
1020 Corporation Way
Palo Alto, CA 94303
Phone:
PI:
Topic#:
(650) 533-9546
Yong Jin Lee
OSD 08-H01      Awarded: 1/8/2009
Title:Multi-Parameter Physiological Monitor
Abstract:There is a critical need for a next generation physiological monitors that can be used to determine the health of the warfighter in the field. Conventional vital signs monitors are typically large, and require a number of cables from the measurement unit to be attached to the patient. It is thus impractical for the warfighter to wear conventional vital signs monitors in the field. It is also impractical for a medic or corpsman to carry the conventional units in the field and attach the various sensors to the warfighter, and manage the cables during transport of the patient. Linea Research Corporation proposed to develop a physiological monitor based on photoplethysmographic techniques that will continuously monitor the heart rate, heart rate variability, beat-to-beat blood pressure, blood oxygen saturation and skin temperature. The unit will compact and wearable, allowing the continuous monitoring of the physiological data through a wireless interface. The monitor unit will provide a self alignment feature that will allow minimally trained personnel, or the warfighter himself, to attach the device to the upper arm. Once the device is attached, it can be worn continuously during field operations or during medical transport from the field to the hospital.

Orbital Research Inc
4415 Euclid Avenue Suite 500
Cleveland, OH 44103
Phone:
PI:
Topic#:
(216) 649-0399
Aaron Rood
OSD 08-H01      Awarded: 1/15/2009
Title:Battle Dress Physiologic Monitor (BDPM)
Abstract:The ability to accurately monitor vital signs in the battlefield is critical to reducing casualties. Orbital Research proposes the Battle Dress Physiologic Monitor (BDPM) a system to monitor changes in general health status. The BDPM will focus on non-inv

UtopiaCompression, Corporation
11150 W. Olympic Blvd. Suite 680
Los Angeles, CA 90064
Phone:
PI:
Topic#:
(310) 473-1500
Jacob Yadegar
OSD 08-H01      Awarded: 12/2/2008
Title:BioSensorWatch: Bio-Sensor Based Health Monitoring Device
Abstract:Hemorrhagic shock is one of the leading causes of death in the battlefield for US war fighters, and is not always easily detectable in early stages before it becomes irreversible. Other types of shocks can also be difficult to detect without a proper continuous monitoring device in place. A monitoring device of this type should be non- invasive in its nature, robust to interference and noise, easily used by medics, other qualified personnel, and possibly end-users and have an efficient power management system. Such a device can be very valuable not only for the different DoD agencies, but also for civil markets. In particular, telemetry applications such as monitoring of vital signs pertaining to sleeping disorders, outpatients’ health status and fitness show great promise. To this end, BioSensorWatch, UtopiaCompression’s proposed system, will monitor and assess changes in the health status of casualties based on real-time processing of various vital sign signals such as oxygen saturation, respiratory and beat- to-beat blood pressure. Our technology hinges on a miniaturized and carefully adapted sensor suite, intelligent power management system, and an innovative and robust decision support system hosted on a hardened PDA like device.

ADVANCED ANTI-TERROR TECHNOLOGIES CORP. (A2T2)
896 W Minneola Ave Suite 57
Clermont , FL 34711
Phone:
PI:
Topic#:
(757) 686-6230
Ringleb
OSD 08-H02      Awarded: 9/23/2008
Title:An Internet-Based Rehabilitation Program for Warriors with Hearing Loss and Auditory Processing Disorders Secondary to Blast and Traumatic Brain Injuries
Abstract:There are often secondary or tertiary effects to blast-related injuries including ear injury and hearing loss, which may also result in cognitive and linguistic deficits. The PALS medical Phase I prototype will be a modular addition to our existing technologies that assist with the rehabilitation of traumatic brain injury and gait training for patients with stroke, cerebral palsy and amputations. It consists of an audio component and multiple visual components, as well as speech recognition, to help the program adapt to the listeners’ abilities. The audio components will include, but will not be limited to listening without interference, listening with background noise (i.e., competing speakers or in a crowd) and listening to accelerated speech. The visual components will include avatars that will help the patient comprehend visual cues, such as lip reading, facial expressions and body language, as well as other components that may be identified during prototype development. Finally, the speech recognition component of this project will allow for the program to adapt to the patients’ listening capabilities, by increasing or decreasing the level of difficulty of the simulation. This tool will be developed while in constant communication with rehabilitation specialists, to ensure that the patients’ needs are met.

APTIMA, INC.
12 Gill Street Suite 1400
Woburn, MA 01801
Phone:
PI:
Topic#:
(781) 496-2452
Jason Sidman
OSD 08-H02      Awarded: 9/16/2008
Title:Adaptive Game for Auditory Training and Evaluation (AGATE)
Abstract:Traumatic Brain Injury (TBI) has been called the signature wound of Operation Iraqi Freedom. The rise in overall survival rates and increase in brain injuries can be attributed to advances in medical technology and Kevlar body armor, which effectively protects soldiers from otherwise fatal blows, but leaves the head and neck area unprotected. The most frequent cause of injuries among more than 22,600 US warfighters, as of November 4, 2006, has been blasts from rocket-propelled grenades, land mines, and improvised explosive devices (IEDs). While current helmets can shield a soldier from penetrating head injuries, they do not absorb kinetic effects resulting from powerful blasts that can lead to closed head injuries, such as TBI. Some likely symptoms of brain injuries include deficits in cognitive processing speed, multitasking, and cognitive endurance; more severe injuries can lead to declines in executive function and self-awareness. Therefore, the development of tools and technologies that compensate for associated deficits is imperative. Aptima proposes to develop a prototype of the Adaptive Game for Auditory Training and Evaluation (AGATE) to train those with central auditory processing disorders. AGATE will be an internet delivered, game based, adaptive trainer.

CREARE, INC.
P.O. Box 71
Hanover, NH 03755
Phone:
PI:
Topic#:
(603) 643-3800
Odile H. Clavier
OSD 08-H02      Awarded: 9/23/2008
Title:Serious Game for Rehabilitation of Auditory Processing Disorders
Abstract:A large proportion of patients suffering from blast-related injuries also suffer from traumatic brain injury. Traumatic brain injury often leads to communication impairments associated with (central) auditory processing disorders ((C)APD). Properly designed auditory training has been shown to improve central auditory processing in patients suffering from (C)APD. Creare’s Serious Game for the Rehabilitation of Central Auditory Processes provides a modular audio, visual, and combined audio-visual rehabilitation tool within an Internet-based client–server application that is fully compatible with Internet distribution. The software tool will integrate rehabilitative scenarios that address the primary central auditory functions. The rehabilitative tool will be engaging, adaptive, and rewarding to ensure maximum benefits and patient compliance to the rehabilitation program.

COMPUTER TECHNOLOGY ASSOC., INC.
12530 Parklawn Drive, Suite 470
Rockville, MD 20852
Phone:
PI:
Topic#:
(301) 581-3270
William Kelley
OSD 08-H03      Awarded: 9/30/2008
Title:Automated Patient Safety Ordering System
Abstract:This submission addresses the development of a Clinical Decision Support (CDS) capability designed to enhance medication safety when used in conjunction with existing and/or new Military Health Systems (MHS) Computerized Physician Order Entry (CPOE), Electronic Medical Record (EMR) and Pharmacy Data Transaction System (PDTS) capabilities. The envisioned CDS system will monitor HL7 messages and use a rule- based engine combined with data mining functionality to generate alerts that will facilitate: 1) drug reconciliations across the spectrum of care, 2) drug contraindication screening using patient-specific data; 3) monitoring for therapeutic failure associated with medications; 4) dosage checking; and 5) ensuring that corollary orders are written as needed. Patient-specific data to be included in dosing and corollary order-class rules include allergies, age, weight, GFR, liver functions, concomitant medications and co- morbidities. The CDS architecture will be “loosely coupled” to clinical data sources and applications facilitating the reuse of the capability with any existing Hospital Information System. The CDS will also incorporate powerful yet easy-to-use tools to tailor/create new rules manually as well as a feature to automate the importation of medication knowledge as best evidence evolves and changes from “Structured Product Labeling” standard-based descriptions routinely maintained and published by the Federal Drug Administration (FDA).

DIAMOND VISIONICS LLC
400 Plaza Drive, Suite-A
Vestal, NY 13850
Phone:
PI:
Topic#:
(607) 729-8526
David L. Peters
OSD 08-H03      Awarded: 9/30/2008
Title:Automated Patient Safety Ordering System
Abstract:Diamond Visionics (DVC) will leverage its application software development experience to evaluate the feasibility and develop a Clinical Decision Support (CDS) system for CPOE used by the Military and VA system. DVC will design and develop a modular CDS system that will have an editor capability and an adjustable override feature. DVC will check the feasibility and develop a prototype CDS system that will have a basic and an advanced patient safety feature. This system will also enable drug reconciliations across levels of care and be compliant with HL7 standards

ARCHIEMD, INC.
1602 ALTON RD , SUITE 126
MIAMI BEACH , FL 33139
Phone:
PI:
Topic#:
(305) 981-4830
Robert Levine
OSD 08-H04      Awarded: 1/6/2009
Title:A Framework for Developing Micro-Games for Preventive Medicine
Abstract:ArchieMD, Inc. proposes to develop a framework for rapidly creating military-relevant micro-games. The utility of the framework will be validated through the creation of a micro-game targeted at reducing leishmaniasis among military personnel deployed to Iraq and Afghanistan. These games SCORM compliant web-deliverable games will be created using Adobe Flash. The objective is to present preventive health information in a manner that engages users’ interest During Phase I, we will develop an initial micro-game entitles Beat the Baghdad Boil. Beat the Baghdad Boil is targeted at reducing leishmaniasis among military personnel deployed to Iraq and Afghanistan.

INTELLIGENT SYSTEMS TECHNOLOGY, INC.
12122 Victoria Ave
Los Angeles, CA 90066
Phone:
PI:
Topic#:
(310) 581-5440
Azad M. Madni
OSD 08-H04      Awarded: 1/6/2009
Title:MedGames™: Micro Games for Proactive Preventive Medicine
Abstract:Service members today are exposed to a variety of health hazards associated with military service. The DoD is committed to ensuring the health of service members by harnessing appropriate technologies that allow them to develop and maintain an awareness of risks and exploit that knowledge to take proactive, preventive measures. DoD believes that micro games provide a convenient and engaging means for Service members to learn how to practice proactive, preventive medicine. This project is concerned with conducting R&D leading to the development of instructional micro games for this purpose. Phase I is concerned with researching the feasibility, risks and cost- effectiveness of educational micro games for learning proactive, preventive medicine.

MYMIC LLC
200 High Street Suite 308
Portsmouth, VA 23704
Phone:
PI:
Topic#:
(757) 391-9200
Taryn Cuper
OSD 08-H04      Awarded: 1/26/2009
Title:Micro Games for Proactive Preventive Medicine
Abstract:MYMIC, LLC and Eastern Virginia Medical School (EVMS) will address the need for Service member preventive medicine education with design FIT-Health, an updateable, multi-genre authoring system for micro-games for health risk awareness. These short and stimulating game-based lessons will build upon one another to leverage new and existing knowledge within a region-specific suite while giving the learner control over their education through presentation mode. Development will be approached in an interdisciplinary fashion in order to address the content and instructional design of the games and the technology-based system design. FIT-Health will create a sense of engagement in a short period of time that will persist over several presentations, similar to television sitcoms. In addition, the games will be updateable to ensure the dissemination of current information to Service members. Last, FIT-Health will be developed for adaptation to mobile platforms, which will ensure that access can occur anywhere at any time, by utilizing a cross-platform authoring tool. This ubiquitous solution will consist of games that both engage the learner and promote learning transfer, resulting in a motivated learner and a successful learning experience.

ONTAR CORP.
9 Village Way
North Andover, MA 01845
Phone:
PI:
Topic#:
(978) 689-9622
John Schoeder
OSD 08-H04      Awarded: 1/13/2009
Title:Micro Games for Proactive Preventive Medicine
Abstract:The OSD is aware that our nation’s younger generations are gamers and have the potential to learn through gaming. OSD has expressed interest in using short duration video games, called micro games, to promote learning in the domain of preventative medicine. Our primary focus during Phase I of this SBIR will be to develop meaningful micro games built on the principles of learning which can be hosted in an educational, web-based system. We will demonstrate the approach with games forealth risk assessment, immunization, screening for diseases, and nutrition. As a proof-of-concept, Ontar will produce two micro games relevant to the preventative medicine topic and demonstrate how our system can develop, host, and distribute training material related to the medical community. At the conclusion of Phase I we will deliver to the OSD a proof- of-concept demonstration for a preventive medicine training hardware and software system.

PLANET LLC
1212 Fourier Drive
Madison, WI 53717
Phone:
PI:
Topic#:
(608) 827-5555
Abe Megahed
OSD 08-H04      Awarded: 1/6/2009
Title:Micro Games for Proactive Preventive Medicine
Abstract:The DoD has put forward several new initiatives that emphasize fitness, preparedness, and preventive medicine through a focus on healthy lifestyle choices and accident prevention. Since a high percentage of the military affected by these issues are surprisingly young, one strategy for engaging this internet-savvy demographic and their families is through proactive preventive medicine microgames. PLANET LLC proposes to use a unique web-based platform for delivering a trio of 3D microgames based on existing medical and allied health knowledge of military preventive health priorities that will move beyond common microgame design to provide a more engaging method for delivery of didactic instruction. Using 3D, games can have a broader opportunity to take players into a role or environment they could normally not enter, allowing them to maximize a learning experience (in hazard or environmental exposure prevention for example). 3D simulation can also place a player in a dramatic situation, offering opportunities for compelling experiential learning. For traditional gaming, 3D also enhances the visual experience and user interactivity. This platform also includes multiplayer capabilities, so social interaction and sharing of ideas and strategies can further engage the players or an instructor and increase the game’s ability to provide instruction.

GenArraytion Inc
9700 Great Seneca highway Suite 325
Rockville, MD 20850
Phone:
PI:
Topic#:
(240) 453-6312
R. Paul Schaudies
OSD 08-H05      Awarded: 2/19/2009
Title:Development of Biomarkers for Clinical Assessment of Occult Infection and Forecasting Emerging Disease Outbreaks
Abstract:Members of the United States Armed Forces are faced with a wide variety of existing, genetically engineered and emerging biological threats. There is a critical need for a fieldable system for rapid microbial assessment of environmental and clinical samples. A system is needed to identify signatures in a complex background with extremely low false positives. Genetic biomarkers target molecular elements that are key to determining course of action, such as virulence mechanisms and antibiotic resistance. GenArraytion proposes to develop a signature sequence microarray for various Staphylococcus aureus strains, including those that are antibiotic resistant. Our hybridization based microsequencing approach provides rapid, accurate and sensitive identification and characterization for early detection of outbreaks. The massively parallel genetic analysis can identify novel, previously uncharacterized organisms and can be automated for field and hospital use. GenArraytion’s Sniper Sequencing identifies hundreds to thousands of unique and functional biomarkers per genome, including markers that are specific at the genus, species and strain levels. Functional elements of pathogens, such as virulence factors, infectious pathway elements and antibiotic resistance, are combined with organism-specific signatures to provide a detailed fingerprint that can discriminate between closely related microbial strains, characterize previously unknown strains, and provide indications of genetic manipulation.

Protein Express, Inc.
9940 Reading Rd
Evendale, OH 45241
Phone:
PI:
Topic#:
(513) 769-9654
Michael L Howell
OSD 08-H05      Awarded: 2/19/2009
Title:Biomarkers for Occult Neural Infectious Disease
Abstract:Despite years of research, the etiology of senile dementia of the Alzheimer’s type (AD) is still unknown. Infectious agents have never been ruled out, and our reliminary studies suggest that bacteria derived from AD brain slices cultured in our novel EBTKS medium may be involved. To identify these bacteria, brain slices will be cultured and non-human DNA sequences derived from the culture by massively parallel means. These sequences will permit (1) the determination of diagnostic PCR primer sets and (2) antigenic peptides that may be used to develop antibody-based diagnostic reagents.

ATTENTION CONTROL SYSTEMS, INC.
650 Castro Street Suite 120, PMB 197
Mountain View, CA 94041
Phone:
PI:
Topic#:
(650) 494-2002
Richard Levinson
OSD 08-H06      Awarded: 9/24/2008
Title:A Conversational Independent Living Assistant for Cognitive Impairments
Abstract:When a patient starts working with a new human caregiver it takes time and talking to develop trust and acceptance, and we should expect the same for electronic cognitive assistants. Human caregivers also function independently from the patient. While existing electronic cognitive aids simply echo the user's schedule back to them, human caregivers think independently about the best way to cue the user in a given situation. We propose to develop an Independent Living Assistant that interacts with patients in a similar way, by using a human-like face and a "conversational" ability to discuss preferences and options with the user. We will extend a commercial cognitive aid already being used by the VA, by adding physiological sensors to detect panic attacks and other psychological symptoms. The system may detect when users avoid activities, and converse with users during in-vivo exposure sessions to collect physiological data as well as their reported in- vivo experience, in order to determine if and when the patient is ready to move to the next level. Anticipated benefits of the system include increased user independence and reduced long-term caregiver costs. Our Medical Advisory Board includes two VA neuropsychologists who will provide guidance about clinical and commercial considerations.

CAMRIS INTERNATIONAL, INC.
1801 Rockville Pike Suite 410
Rockville, MD 20852
Phone:
PI:
Topic#:
(301) 770-6000
Maria Trujillo
OSD 08-H06      Awarded: 9/30/2008
Title:Interactive Cognitive Interface and Health Monitoring System
Abstract:Soldiers coping with injuries such as Traumatic Brain Injury and Post Traumatic Stress Disorder (MCI/TBI) are in need of innovative solutions that will attempt to make their daily functioning easier while gaining independence. Even though soldiers with such injuries may be high functioning in some aspects of life, they still require a compensatory strategy for performing activities of daily living. The CAMRIS/CogniFit team will develop the initial plan, concept design and illustration for an interactive, low cost, effective cognitive interface system to support soldiers living with minor cognitive impairments. The Personal Autominder Coach Enhancement (PACE) system will focus on supporting some activities of daily living and provide assistance in self health maintenance by identifying each user's cognitive weaknesses. The proposed PACE system will interact with Autominder (Pollack 2006) developed for both older adults and with patients of various ages who have traumatic brain injury using advanced Artificial Intelligence techniques. We intend to enhance on the psychosocial aspects of health provider and patient interaction by using a “personal coach” approach that will include trust and affect, which have been shown to change treatment outcomes. We concur with the fact that augmenting trust between human users and machines have also been shown to influence the combined system performance. Our approach incorporates techniques used in building computational social agents (Miller, 2004) to encourage meaningful human-system interactions. By building a training routine based on user weaknesses, we believe we will create a significant improvement in overall functioning of MCI soldiers.

INGENIUM CARE, LLC
10311 W. Hampden Avenue Suite A-107
Lakewood, CO 80227
Phone:
PI:
Topic#:
(303) 989-3424
James Wolf
OSD 08-H06      Awarded: 9/23/2008
Title:Interactive Cognitive Interface and Health Monitoring System
Abstract:More soldiers are surviving battle injuries than ever before. However, many of the survivors suffer traumatic brain injuries, post traumatic stress disorder. These soldiers require care beyond the acute care provided by the hospitals. As they transition from acute care into extended care and independent living conditions, they need assistance and supervision to facilitate rehabilitation from injury, impairment or disability. This proposal describes a system capable of delivering such assistance and remote care while addressing the requirements for self health maintenance, safety and security, medical treatment (including therapy and rehabilitation) and social needs. The proposed system consists of a mesh network of fixed and wearable wireless type devices placed into the dwelling of the patient. The sensor network allows tracking the patient’s movement, to ascertain the basic health of the patient, to establish performance of certain activities and to provide assistance through intelligent prompting. Data gathered by the sensors is transmitted wirelessly to an in-home cognitive server and processed to provide an adaptive level of assistance to the patient and alerting of caregivers. A PDA Cellular Phone gateway will allow the patient to leave the dwelling and still maintain connection to the POC and the remote monitoring stations.

SMART INFORMATION FLOW TECHNOLOGIES, D/B/A SIFT
211 N 1st St. Suite 300
Minneapolis, MN 55401
Phone:
PI:
Topic#:
(612) 669-6224
Peggy Wu
OSD 08-H06      Awarded: 9/18/2008
Title:Sensing Using Physical and Psychological Observations for Rehabilitating Troops (SUPPORT)
Abstract:The injuries of today's returning soldiers are dramatically different than those of previous deployments and necessitate unique forms of support. There have been increased incidences of Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD), and early intervention can reduce the severity of the disease and the cost of treatment, but we lack the human and technology resources for early diagnosis. This project builds upon assistive technologies for independent living by using a holistic approach that addresses both physical and emotional needs. We propose to create comprehensive designs for the underlying architecture and some key components of SUPPORT, a tool for recovering troops and caregivers to monitor health and well being, be alerted of potential problems, and manage treatment regimes. SUPPORT will use contextual cross referencing of physiological and psychological measures to accurately assess patient conditions. We will use advanced user interface design techniques that leverage human interaction theory combined with a cognitive orthotic system that utilizes sophisticated scheduling and planning algorithms to produce a non-intrusive yet highly interactive solution that encourages prolonged user engagement and human-machine collaboration for long term self-care, provides tools for patient-caregiver communication, and facilitates preventative care by early diagnosis of disease symptoms.

TALKING LIGHTS LLC
28 Constitution Road
Boston, MA 02129
Phone:
PI:
Topic#:
(617) 242-0050
Elmer C. Lupton
OSD 08-H06      Awarded: 9/23/2008
Title:Cognitive Orthotic for Traumatic Brain Injury Patients
Abstract:This Phase I SBIR will develop assistive technology for person recovering from Traumatic Brain Injury(TBI). The patient will receive individualized audio guidance as they use articles of daily living and travel within their rehab facility. The patient carries a cellphone programmed with daily schedule and facility map. Talking Lights(TL) technology will enable ordinary lights to become location beacons while still providing satisfactory non- flickering iillumination. A small, lightweight receiver carried by the patient processes data from TL beacons to communicate location to the patients cellphone/computer. Articles of daily living are mesh networked with the patient and a central server to real-time, interactive guidance. The system has shown substantial benefit in improving patient travels and scheduling. This project will extend the capability to articles of daily living and will reduce size and weight, extend battery life and greatly enhance capability. Because the system uses existing lighting infrastructure and COTS cellphone, it is inexpensive and quick and easy to implement The system tracks and records patient location and activities and is used for tracking and safety monitoring even when the patient no longer needs audio guidance. It is suitable for acute care, post acute care and at home rehab.

APTIMA, INC.
12 Gill Street Suite 1400
Woburn, MA 01801
Phone:
PI:
Topic#:
(781) 496-2476
Robert McCormack
OSD 08-H07      Awarded: 9/18/2008
Title:Automated Knowledge Structuring of Medical Charts Data
Abstract:Some major military health problems are caused or exacerbated by environmental factors. Gulf War Syndrome, reactions to Agent Orange, and other such problems tend to have diverse symptoms and delayed (and variable) latencies to onset. A major reason they are so difficult to identify, diagnose, and manage is capability shortfalls in military (and civilian) medical information systems. Linkages among systems are sub-optimal (although being vigorously pursued). Critically, tools do not exist that support the kinds of information analysis, extraction, and exploration required in current and future data sources. Aptima and its partner, the University of Colorado Computational Bioscience Program, propose to design (in Phase I) and develop (in Phase II) a toolset called Automated Structuring of Knowledge for Medical Extraction of Data (ASK-MED). ASK-MED will enable military medical professionals to find clinically-relevant patterns in data across various information systems. Our strategy avoids the technical tarpit of ontology alignment and instead integrates a powerful top-down, ontology-neutral knowledge-based method with bottom- up, domain-independent statistical language analysis technique. The solution will add value to existing informatics efforts, without requiring that all the surrounding institutional and technical problems be solved.

KNOWLEDGE BASED SYSTEMS, INC.
1408 University Drive East
College Station, TX 77840
Phone:
PI:
Topic#:
(979) 260-5274
Madhav Erraguntla
OSD 08-H07      Awarded: 9/30/2008
Title:Environment, Epidemiology, and Etiology Surveillance and Analysis Toolkit (E3SAT)
Abstract:The goal of this SBIR initiative is to design and develop an Environment, Epidemiology, and Etiology Surveillance and Analysis Toolkit (E3SAT) that will provide a research data cube and analysis tool suite to enable researchers to collect, integrate and data mine medical records, environmental exposures, and deployment locations. The data assembled will include medical records including signs, symptoms, diagnosis, orders, and outcomes (from AHLTA system), environmental issues (from DOEHRS system), and deployment profiles. The analysis supported includes environmental, epidemiological and etiological issues, causes and effects, discovery of correlations and causalities, and hypothesis testing. E3SAT will supplement the standard data available from AHLTA and DOEHRS with information retrieved from public sources on local and regional environmental patterns and with epidemiology information. It will accept inputs and annotations from Subject Matter Experts (SME) related to environmental data as well as hypotheses that need to be validated. E3SAT allows researchers and practitioners to interact seamlessly with the integrated analysis cube and for a time phased longitudinal view of individual records as well as latitudinal view across multiple soldiers. It allows for drill down into data supporting a discovered hypothesis, epidemiology, and pattern; or drilling up to view similar symptoms or environmental exposure cluster.

PROGENY SYSTEMS CORP.
9500 Innovation Drive
Manassas, VA 20110
Phone:
PI:
Topic#:
(703) 368-6107
Gary Sikora
OSD 08-H07      Awarded: 9/30/2008
Title:Automated Knowledge Structuring of Medical Charts Data
Abstract:We offer an Environmental Surveillance Framework that will have the ability to quickly run data filters over a consolidated set of medical charts to “raise red flags” and draw attention to anomalies used to help identify the onset or origin of changes in health functionally acting as diagnostic decision aids. The ability to trace results back to the original individual medical cases, for evaluators to create and edit filters so data can be evaluated in real or near real- time. The Environmental Surveillance Framework comprises three major components to extract, understand and access the data. The first component extracts and encodes narrative free text from databases such as AHLTA using natural language processing (NLP) with an ontology. The second component harmonizes extracted data elements with other databases and data sources such as environmental site locations (e.g. oil wells, land fills, etc.) and news feeds using an ontology to mediate different database constructs and datasets. The third component provides user interfaces and query tools. The architecture approach is to be non-invasive, so for example changes to the AHLTA system are not required, all we need is access to the knowledgebase.

TEKSOUTH CORP.
1420 Northbrook Drive Suite 220
Gardendale, AL 35071
Phone:
PI:
Topic#:
(937) 554-4673
Stephen Lahanas
OSD 08-H07      Awarded: 9/30/2008
Title:Automated Knowledge Structuring of Medical Charts Data
Abstract:The Personal and Group Healthcare Portfolio Concept represents a revolutionary shift in thinking about the architecture and solutions design for the next generation of Healthcare Management and Bio-Informatics systems. This proposal is dedicated upon the proposition that the only architectural approach that can accommodate the level of complexity likely to be associated with tomorrow’s healthcare challenges is one built around a “services” paradigm. A services oriented healthcare solution supports any number of federated data sources and allows for flexibility, agility and dynamic adaptability. Those services when viewed holistically and presented in contextual views represent Healthcare Portfolios – these are more than records , more than portals and more than single EHR systems. A Portfolio is a user-defined semantic context engine and analytics platform. The goal with our solution is not to hard-code all knowledge and outcomes within it but rather to build the solution so that it can be extended as needed. Medical knowledge is dynamic; new discoveries are made every day and massive amounts of data require analysis– both for individuals and entire populations. As our insights improve, we will need to have the ability to reapply them to existing knowledge. The Healthcare Portfolio framework delivers that capability.

VECNA TECHNOLOGIES, INC.
5004 Lehigh Avenue
College Park, MD 20740
Phone:
PI:
Topic#:
(703) 998-5333
Alvin Ramsey
OSD 08-H07      Awarded: 9/25/2008
Title:Automated Knowledge Structuring of Medical Charts Data
Abstract:Vecna proposes to develop a system with the ability to automatically process and filter through medical records to help identify anomalies and to aid in clinical decision support. The system will be able to automatically process individual as well as aggregate medical records, and the user interface to the system will conform with current clinical work flows and processes.

ARCHIEMD, INC.
1602 ALTON RD , SUITE 126
MIAMI BEACH , FL 33139
Phone:
PI:
Topic#:
(305) 981-4830
Robert Levine
OSD 08-H08      Awarded: 9/24/2008
Title:An Augmented Reality Training System for Treatment of Battlefield Injuries
Abstract:ArchieMD, Inc. and Medical Education Technologies, Inc. (METI) propose to integrate ArchieMD’s multimedia medical education technology with METI’s patient simulator technology using mixed reality goggles. Using mixed reality goggles, 3D imagery will be superimposed over the view of the user. This will enable the user to get additional 3D didactic information while using the patient simulator. During Phase I, we will demonstrate the ability to superimpose 3D graphic simulations of tension pneumothorax over a METI mannequin shell. This SBIR project will demonstrate proof of concept of this revolutionary new teaching model.

CHI SYSTEMS, INC.
1035 Virginia Drive Suite 300
Fort Washington, PA 19034
Phone:
PI:
Topic#:
(407) 277-9288
Jennifer Fowlkes
OSD 08-H08      Awarded: 9/30/2008
Title:Augmented Reality for Enhancing Combat Medic Skills Training (MedSkills)
Abstract:Combat medics provide battlefield medical care under austere conditions and respond to traumas less frequently seen in civilian settings. CHI Systems, Inc. proposes to team with the Institute for Simulation and Training to address training for combat medics through the application of augmented reality technologies combined with manikins and immersive simulations. Specifically, in Phase I, we propose to establish the technical feasibility and training effectiveness of MedSkills, a pedagogically sound training system focused on training combat medics in levels of care that include care under fire, tactical field care and casualty evacuation – the “Golden Hour”. We will explore the use of augmented reality to enhance visualization of severe trauma and underlying physiological mechanisms and to support trainee performance (e.g., guide trainees, provide feedback). Phase I tasks include a cognitive task analysis to understand the competencies and knowledge requirements associated with combat medicine; a technology analysis to guide the application of augmented reality technologies to meet training requirements; and research conducted to evaluate the impact of augmented reality technologies on trainee understanding. In addition, in Phase I we will lay the groundwork for the successful development of MedSkills by planning for multi-phased development, evaluation, and transition in Phase II.

CYBERNET SYSTEMS CORP.
727 Airport Boulevard
Ann Arbor, MI 48108
Phone:
PI:
Topic#:
(734) 668-2567
Ronald Hay
OSD 08-H08      Awarded: 9/30/2008
Title:Augmented Reality Systems for Training Health Care Providers
Abstract:During the Phase I period of this contract we will research and develop a Phase II development plan for creating an augmented reality serious game for medic training. Our primary technical research will focus on: • Dynamic augmented reality registration of deformable surface. • 3D Stereoscopic video and MRI/ultrasound augmented reality overlays. • Real-time occlusion tracking, particularly of the hands. • Medical gesture recognition for task completion. • User-generated, and open-source game content interfaces. • Novel scoring systems that account for the user’s behavior and react naturally. This scoring system requires a detailed understanding of what tasks should be completed at anytime, as well as team task behaviors. • Maintaining realistic haptic feedback for the simulation participants so as the augmented/virtual components of the simulation merge seamlessly with the real world. Working with the sponsor and our affiliates in the serious games, medical, and DoD domains we will: • Locate candidate groups for final testing and develop simulation validation techniques. • Research and attend and potentially publish at relevant industry conferences. • Discover potential customers for commercialization including customers in the private and DoD domains

TOUCH OF LIFE TECHNOLOGIES
12635 East Montview Boulevard Suite 100
Aurora, CO 80045
Phone:
PI:
Topic#:
(720) 859-4177
Ron Hightower
OSD 08-H08      Awarded: 9/30/2008
Title:Augmented Reality Systems for Training Health Care Providers
Abstract:Responding to trauma cases effectively requires an understanding of underlying anatomy and pathologies. A training system can help develop a student's understanding by displaying the internal anatomy in a meaningful context--the context of an actual patient. Augmented Reality provides exactly this type of visualization, showing computer generated images in a real-world context. ToLTech proposes to enhance the effectiveness of mannequin-based training simulators with Augmented Reality, utilizing our experience in building and interacting with virtual anatomy.

APTIMA, INC.
12 Gill Street Suite 1400
Woburn, MA 01801
Phone:
PI:
Topic#:
(781) 496-2480
Jeffrey Beaubien
OSD 08-H09      Awarded: 9/23/2008
Title:The IMPACT Surgical Skills Trainer: Using Deliberate Practice to Maintain Specialized Surgical Knowledge and Skills During Deployments
Abstract:While on deployment, many military surgeons spend the bulk of their time performing trauma surgery. Because combat deployments frequently average one full year, such prolonged lapses in practice can degrade specialized knowledge and skills. This becomes a major problem upon the surgeons’ return stateside, when they are expected to resume their surgical specialty duties with little or no re-credentialing. The envisioned product of this SBIR is the IMPACTTM Surgical Skills Trainer, a deployable, SCORM-compliant training program that will help military surgeons maintain their specialty knowledge and skills. During Phase I, Aptima will conduct a cognitive task analysis (CTA) to identify the critical training needs. Next, Aptima will develop a fully-functional training program with a representative set of learning modules. Finally, Aptima will develop plans for evaluating IMPACTTM’s effectiveness during Phase II. During Phase II, Aptima will fully develop the remainder of the IMPACTTM training content and add new system functionality to enhance the learning experience. The end result will be a surgical training curriculum that is specifically designed to help deployed surgeons minimize specialized knowledge and skill decay.

ARCHIEMD, INC.
1602 ALTON RD , SUITE 126
MIAMI BEACH , FL 33139
Phone:
PI:
Topic#:
(305) 981-4830
Robert Levine
OSD 08-H09      Awarded: 9/23/2008
Title:A 3-D Multimedia Training System for Surgical Treatment Battlefield Orthopedic Injuries
Abstract:Orthopedic injuries have comprised a majority of combat injuries in most recent conflicts. These orthopedic injuries are significantly different than those experienced in the civilian sector, making it difficult for military orthopedic surgeons to develop and sustain battlefield-relevant surgical skills. ArchieMD, Inc. proposes to develop a 3-D Multimedia Training System for Treatment Battlefield Orthopedic Injuries. This training system integrate visual 3-D computer models, video recording of the actual treatments, and an interactive virtual patient to develop a comprehensive, effective training tool for Army, Air Force, and Navy medical personnel. We believe this will be highly effective given the nature of both the visual component and the “hands on” component of medical education. The resultant system will include the input of subject-matter experts and be rigorously evaluated to determine its didactic value throughout the development process.

SIMQUEST, LLC
1010 Wayne Avenue, Suite 940
Silver Spring, MD 20910
Phone:
PI:
Topic#:
(301) 587-9440
Howard Champion
OSD 08-H09      Awarded: 9/30/2008
Title:Advanced Distributed Learning in Support of the Maintenance of Certification (MOC) of Surgical Skills
Abstract:Maintenance of certification and clinical competence for deployed military medical personnel presents formidable challenges. SimQuest, a small business with an established track record in innovative technology-assisted educational approaches and products, will successfully link the military medical personnel requiring maintenance of competence in general surgery and their hierarchy with the certifying organization, the American Board of Surgery (ABS), to develop a credible plan for innovative approaches to sustaining and maintaining competence while deployed and upon reinsertion into continental United States (CONUS) practice following deployment. A detailed assessment of specific end-user needs and constraints will guide the development of a plan that can be accepted by the certifying agency. An advanced distributed learning (ADL), adult student-centered, case scenario-based product involving intelligent tutoring and assessment will be proposed with various components tuned to specific end-user needs. An “open” platform will enable game-based, compelling contributions from various sources. This platform will be designed to be integrated with other CME and recertifying initiatives, particularly those that are being proposed in conjunction with the ABS and with SimQuest’s surgical skills training assessment platform.

SYSTEMS ENGINEERING, INC.
PO Box 2608
Springfield, VA 22152
Phone:
PI:
Topic#:
(253) 678-5151
Mark Hickey
OSD 08-H09      Awarded: 9/30/2008
Title:Advanced Distributed Learning in Support of the Maintenance of Certification (MOC) of Surgical Skills
Abstract:The rapid increase in the growth of surgical knowledge and the introduction of new technologies have made the idea of giving a written recertification examination every ten years to measure surgical skill competency seem archaic and inadequate. A new set of requirements that physicians must adhere to in order to maintain their certification status started in 2005. The new program is called ABMS Maintenance of CertificationÒ (abbreviated MOC). In MOC, there is a requirement to continuously participate in learning, self-assessment, and practice improvement. Satisfying this aspect of MOC is very difficult for military surgeons deployed outside CONUS who do not have access to traditional learning environments like professional meetings and courses. Using an innovative mix of reusable intelligent tutoring functions, comprehensive analysis, adaptive learning approaches, engaging learning content, Advanced Distributed Learning strategies, and American Board of Surgery approved medical curriculum, SEI seeks to demonstrate a commercially viable solution that enables surgical personnel to engage in lifelong learning to gain clinical knowledge and skills within their specialty while in deployed status.

TOUCH OF LIFE TECHNOLOGIES
12635 East Montview Boulevard Suite 100
Aurora, CO 80045
Phone:
PI:
Topic#:
(720) 859-4178
Karl Reinig
OSD 08-H09      Awarded: 9/30/2008
Title:Advanced Distributed Learning in Support of the Maintenance of Certification (MOC) of Surgical Skills
Abstract:Deployed surgeons spend long periods of time isolated from their normal practice. This adds the difficulty of maintaining their specialized skills to the long list of hardships and further complicates their return. ToLTech proposes to combine the considerable wealth of electronic resources that the AAOS has to offer with web-based virtual surgeries to produce a compelling skills development and retention program accessible anywhere in the world. While this effort will focus on maintenance of orthopaedic surgical skills, the basic technologies to be developed and demonstrated during this effort will be applicable to all surgical specialties.

ACREE TECHNOLOGIES, INC.
1980 Olivera Road Suite D
Concord, CA 94520
Phone:
PI:
Topic#:
(925) 798-5770
Jeff Brown
OSD 08-H10      Awarded: 9/22/2008
Title:Diamond-like Carbon Coatings on Polymers
Abstract:The purpose of this proposal is to demonstrate the effectiveness of an innovative multilayer scratch, abrasion, and ballistic impact resistant protective coating for eyewear that uses a Diamond-Like-Carbon (DLC) coating as the topcoat. The design consists of an optically thick buffer layer that is first deposited on the polycarbonate that has a refractive index closely matched to that of the polycarbonate substrate. This layer provides an optically transparent and mechanically resilient “foundation” and substantially improves the load bearing capability of the plastic substrate. The optical index match allows the coating thickness to be adjusted to maximize mechanical performance without affecting the optical performance. This thick buffer layer is then followed with a series of thinner layers including a DLC top-coat to provide excellent scratch, abrasion and ballistic impact resistance. The additional layers between the DLC and buffer layer allow improved optical performance by impedance matching the layer structure to air. The result of this optimized layer structure is a dramatically improved wear resistance, including abrasive and impact, when compared to the current polycarbonate lenses with scratch resistant AR coatings. The coating can be applied inexpensively in Acree’s Large Volume Coater (LVC).

NANOSONIC, INC.
P.O. Box 618
Christiansburg, VA 24068
Phone:
PI:
Topic#:
(540) 953-1785
Vince Baranauskas
OSD 08-H10      Awarded: 9/22/2008
Title:Ballistic Resistant, Environmentally Robust Hybrid Polysiloxane Nanocomposites as Optically Transparent Protective Coatings for Polycarbonate Protective Equipment
Abstract:The objective of this Phase I SBIR program is to design, synthesize and qualify innovative optically transparent ballistic and abrasion resistant hybrid polysiloxane nanocomposites for use as protective coatings on polycarbonate protective equipment. Researchers will synergistically combine the molecular mobility, impact durability and mechanical strength of hybrid polysiloxane copolymers with the abrasion resistance of reinforcing metal oxide nanoparticles to afford novel protective coatings that enhance the high velocity impact resistance, strength and abrasion resistance of polycarbonate equipment. The proposed copolymer coatings will be an extension of NanoSonic’s blast / flame protective polysiloxane coatings that have demonstrated 1) V50 values > 4,000 ft/s to 3/8” A36 steel panels (MIL-STD-662F), 2) multiple shot protection from 0.50 cal rounds and 3) exceptional flame resistance. Of particular interest, NanoSonic’s hybrid polysiloxane protective materials have demonstrated a 53% V50 enhancement over uncoated steel panels and a 43% V50 improvement over currently employed polyurea protective coatings. NanoSonic specializes in the coating of polycarbonate substrates and has previously developed optically transparent multifunctional abrasion resistant coatings for NAVAIR aircraft canopies. During this program, researchers will leverage this technology and NanoSonic’s recently developed hybrid polysiloxane coatings to produce innovative optically transparent, abrasion resistant antiballistic coatings for polycarbonate equipment.

SURMET CORP.
31 B Street
Burlington, MA 01803
Phone:
PI:
Topic#:
(781) 345-5770
Suri A. Sastri
OSD 08-H10      Awarded: 9/18/2008
Title:High Strength, Durable Coating Technology for Application to Polymer Based Eye Protection Gears
Abstract:Surmet Corporation proposes to explore its plasma-assisted chemical vapor deposition (PACVD) based hard coating treatment to produce transparent coated polymer substrates for protective soldier eyewear products. We will design, develop and test proprietary hard coatings on polycarbonate to exhibit good adhesion, scratch and abrasion resistance, transparency and durability under harsh environment loading such as humidity, temperature cycling, UV exposure and dust/sand erosion. Additionally, toughness and ballistic performance of the coated specimens will be determined for comparison to the baseline uncoated polycarbonate substrate. Scientists at Surmet have long been involved in development, application of hard diamond-like-carbon (DLC) based and other composite coatings for number of material surfaces, and have a proven record of achieving desired results. Surmet has substantial experience in developing and commercializing coatings technologies. In this SBIR program, Phase I will prove feasibility and effectiveness of our technology, Phase II will optimize materials and processes, and prove repeatability in performance of coated articles along with scale-up to full-scale size.

SYSTEMS & MATERIALS RESEARCH CORP.
1300 West Koenig Lane Suite 230
Austin, TX 78756
Phone:
PI:
Topic#:
(512) 535-7791
Denise Deppe
OSD 08-H10      Awarded: 9/19/2008
Title:Diamond-like Carbon Coatings on Polymers
Abstract:Transparent armor is an important piece of equipment for the war fighter in today's dangerous battlefields. With advances in weaponry, more ballistic resistant transparent armor is needed to keep our soldiers safe. SMRC proposes a clay-polymer nanocomposite coating to help increase the ballistic protection and abrasion resistance of current transparent armor solutions while maintaining optical clarity. The proposed coating, applied via layer-by-layer (LbL) self-assembly, is advantageous over more traditional methods in that it can be deposited at room temperature with a simple dip-rinse- repeat process. Preliminary experiments show a 5 % increase in V50 ballistic limit for a 6 clay-polymer bilayer coating deposited on polycarbonate when compared to neat polycarbonate. Additional layers and other polymers are expected to give an even better response. PPG Aerospace's Transparent Armor and Specialty Products Division has expressed interest in developing this coating technology.